Cervical cytology and HPV distribution in Cape Verde: A snapshot of a country taken during its first HPV nation-wide vaccination campaign

IF 4.7 Q1 VIROLOGY Tumour Virus Research Pub Date : 2024-06-01 DOI:10.1016/j.tvr.2024.200280
Rita Vieira , Diana Montezuma , Carla Barbosa , Isabel Macedo Pinto
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Abstract

Cervical cancer ranks as the third most common female cancer in Cape Verde and is the leading cause of cancer-related deaths among women in the country. While Human Papillomavirus (HPV) vaccination, which started in 2021, is anticipated to significantly reduce disease incidence, cervical screening remains crucial for non-vaccinated women. We retrospectively reviewed gynecologic cytology exams and HPV tests performed in Cape Verde between 2017 and April 2023 and processed at IMP Diagnostics. For this study, we considered 13035 women with cytology examinations performed and, 2013 of these, also with an HPV molecular test. Cytology diagnostics comprised 83 % NILM cases; 12 % ASC-US; 2.7 % LSIL; 1.2 % ASC-H; 0.5 % HSIL and 0.1 % SCC. In 505 (25.1 %) high-risk HPV infection was detected. Prevalence of HPV infection varied with age, peaking at young ages - ≤24 years old (55.5 %) and 25-35-year-old women (31.5 %) - and the lowest after 66 years old (9.7 %). Herein we present a comprehensive study regarding Cape Verde's cervical cytology and HPV distribution, aiming to provide a snapshot of the country's cervical cytology results and HPV distribution in recent years. Moreover, these data may contribute to establish a baseline to assess, in the future, the vaccination impact in the country.

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佛得角的宫颈细胞学和人类乳头瘤病毒分布情况:首次在全国范围内开展人类乳头瘤病毒疫苗接种活动期间的国家快照。
宫颈癌是佛得角第三大最常见的女性癌症,也是该国妇女因癌症死亡的主要原因。虽然 2021 年开始的人乳头状瘤病毒(HPV)疫苗接种预计将大大降低疾病的发病率,但宫颈筛查对于未接种疫苗的妇女仍然至关重要。我们回顾性地审查了 2017 年至 2023 年 4 月期间在佛得角进行的妇科细胞学检查和 HPV 检测,并在 IMP 诊断公司进行了处理。在这项研究中,我们考虑了 13035 名进行过细胞学检查的女性,其中 2013 名还进行了 HPV 分子检测。细胞学诊断包括83%的NILM病例;12%的ASC-US;2.7%的LSIL;1.2%的ASC-H;0.5%的HSIL和0.1%的SCC。在 505 例(25.1%)中检测到高危 HPV 感染。HPV感染率随年龄而变化,年轻女性感染率最高,≤24岁(55.5%),25-35岁(31.5%),66岁以后感染率最低(9.7%)。在此,我们提交了一份有关佛得角宫颈细胞学和人乳头瘤病毒分布情况的综合研究报告,旨在提供该国近年来宫颈细胞学结果和人乳头瘤病毒分布情况的快照。此外,这些数据还有助于建立一个基线,以便将来评估疫苗接种在该国的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tumour Virus Research
Tumour Virus Research Medicine-Infectious Diseases
CiteScore
6.50
自引率
2.30%
发文量
16
审稿时长
56 days
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