Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis of Cohort Studies.

IF 1.8 4区医学 Q3 PSYCHIATRY Psychiatry Investigation Pub Date : 2024-04-01 Epub Date: 2024-04-23 DOI:10.30773/pi.2021.0134

Meixian Zhang, Zhu Liduzi Jiesisibieke, Ho-Shan Wei, Pei-En Chen, Ching-Wen Chien, Ping Tao, Tao-Hsin Tung

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Abstract

Objective: To assess whether carbon monoxide (CO) poisoning increases the incidence of dementia.

Methods: We searched the Cochrane Library, PubMed, and EMBASE from inception to 14 August 2022. Two authors independently selected studies, assessed the quality of included studies, and extracted data. Any disagreement was resolved by discussion with a third author. Only cohort study with an enough follow-up period was included for systematic reviews and meta-analysis.

Results: Thirty-three full texts were initially searched, but only three studies met our inclusion criteria, and they were comprised of 134,563 participants who were initially free of dementia. The follow-up period ranged from 9 to 12 years. We found that CO poisoning increased the risk of dementia incidence (adjusted hazard ratio 2.61, 95% confidence interval 1.56 to 4.36, p=0.0003). Subgroup analysis showed that the increased dementia risk was significant in males but not in females, and the highest risk was in young age group, followed by in middle age group, but not in the old one.

Conclusion: Overall the evidence from prospective cohort studies supported a link between CO exposure and an increased dementia risk, although all the included studies were limited to Taiwanese population.

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一氧化碳中毒患者患痴呆症的长期风险增加：队列研究的系统回顾和元分析》。

目的：评估一氧化碳（CO）中毒是否会增加痴呆症的发病率：评估一氧化碳（CO）中毒是否会增加痴呆症的发病率：我们检索了从开始到 2022 年 8 月 14 日的 Cochrane 图书馆、PubMed 和 EMBASE。两位作者独立筛选研究、评估纳入研究的质量并提取数据。如有分歧，则与第三位作者讨论解决。只有具有足够随访期的队列研究才被纳入系统综述和荟萃分析：初步检索了 33 篇全文，但只有 3 项研究符合我们的纳入标准，它们由 134563 名最初未患痴呆症的参与者组成。随访时间从 9 年到 12 年不等。我们发现，一氧化碳中毒会增加痴呆症的发病风险（调整后危险比为 2.61，95% 置信区间为 1.56 至 4.36，P=0.0003）。亚组分析表明，男性痴呆症发病风险显著增加，而女性则不显著；年轻组的痴呆症发病风险最高，其次是中年组，但老年组的痴呆症发病风险不高：总体而言，前瞻性队列研究的证据支持一氧化碳暴露与痴呆症风险增加之间存在联系，尽管所有纳入的研究都仅限于台湾人群。

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.