Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY World Journal of Hepatology Pub Date : 2024-03-27 DOI:10.4254/wjh.v16.i3.366

Kanuengnit Choochuay, Punna Kunhapan, Apichaya Puangpetch, Sissades Tongsima, Pornpen Srisawasdi, Abhasnee Sobhonslidsuk, Somnuek Sungkanuparph, Mohitosh Biswas, Chonlaphat Sukasem

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Abstract

Background: The prevalence of metabolic-associated fatty liver disease (MAFLD) is a growing public health issue in people living with human immunodeficiency virus (PLWH). However, the pathophysiology of MAFLD is still unknown, and the role of genetic variables is only now becoming evident.

Aim: To evaluate the associations of gene-polymorphism-related MAFLD in PLWH.

Methods: The study employed transient elastography with a controlled attenuation parameter ≥ 248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand. Candidate single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan^® MGB probe 5' nuclease assays for seven MAFLD-related genes. Statistical analyses included SNP frequency analysis, Fisher's Exact and Chi-square tests, odds ratio calculations, and multivariable logistic regression.

Results: The G-allele carriers of PNPLA3 (rs738409) exhibited a two-fold rise in MAFLD, increasing by 2.5 times in MAFLD with human immunodeficiency virus infection. The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times (P = 0.001) more significant chance of developing aberrant triglyceride among PLWH.

Conclusion: The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH.

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泰国人类免疫缺陷病毒感染者中 PNPLA3 和 LEP 基因多态性与代谢相关性脂肪肝的关系。

背景：在人类免疫缺陷病毒感染者（PLWH）中，代谢相关性脂肪肝（MAFLD）的发病率是一个日益严重的公共卫生问题。然而，MAFLD 的病理生理学尚不清楚，遗传变异的作用现在才逐渐显现出来。目的：评估 PLWH 中与基因多态性相关的 MAFLD 的关联：研究采用瞬态弹性成像技术，控制衰减参数≥ 248 dB/m，以确定泰国中部一家超级三级医院患者的 MAFLD。使用 TaqMan® MGB 探针 5' 核酸酶检测法对七个 MAFLD 相关基因的候选单核苷酸多态性 (SNP) 进行了基因分型。统计分析包括 SNP 频率分析、费雪精确检验和卡方检验、几率计算和多变量逻辑回归：结果：PNPLA3（rs738409）的G等位基因携带者的MAFLD发病率增加了两倍，感染人类免疫缺陷病毒的MAFLD发病率增加了2.5倍。临床特征和遗传模式意味着，在 PLWH 中，LEP rs7799039 A-等位基因携带者发生甘油三酯异常的几率是其他携带者的 9 倍（P = 0.001）：本研究表明，PNPLA3 rs738409 和 LEP rs7799039 与 PLWH 中的 MAFLD 存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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