Inflammatory Memory in Chronic Skin Disease

Joseph A. Daccache , Shruti Naik
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引用次数: 0

Abstract

Inflammation is a hallmark of remitting-relapsing dermatological diseases. Although a large emphasis has been placed on adaptive immune cells as mediators of relapse, evidence in epithelial and innate immune biology suggests that disease memory is widespread. In this study, we bring to the fore the concept of inflammatory memory or nonspecific training of long-lived cells in the skin, highlighting the epigenetic and other mechanisms that propagate memory at the cellular level. We place these findings in the context of psoriasis, a prototypic flaring disease known to have localized memory, and underscore the importance of targeting memory to limit disease flares.

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慢性皮肤病的炎症记忆。
炎症是皮肤病复发的标志。虽然适应性免疫细胞是导致复发的主要因素,但上皮和先天性免疫生物学的证据表明,疾病记忆是普遍存在的。在这项研究中,我们提出了皮肤炎症记忆或长寿命细胞非特异性训练的概念,强调了在细胞水平传播记忆的表观遗传和其他机制。银屑病是一种已知具有局部记忆的典型发作性疾病,我们将这些发现置于银屑病的背景中,并强调了针对记忆限制疾病发作的重要性。
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
0
审稿时长
8 weeks
期刊最新文献
Cover 1 Corrigendum to ‘Proteomic Profiling of CCCA Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation’ JID Innovations, Volume 4, Issue 3, May 2024, 100263 Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank From Plant to Patient: A Historical Perspective and Review of Selected Medicinal Plants in Dermatology Spatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology
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