Molecular Aspects of Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Salivary Gland.

IF 3.2 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2024-04-24 DOI:10.1007/s12105-024-01629-2

Raisa Ferreira Costa, Carolinne Alves de Oliveira, Ágatha Nagli de Mello Gomes, Silvia Vanessa Lourenço, Cláudia Malheiros Coutinho-Camillo

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Abstract

Background: Salivary gland tumors (SGTs) are rare and highly heterogeneous lesions, making diagnosis a challenging activity. In addition, the small number of studies and samples evaluated difficults the determination of prognosis and diagnosis. Despite the solid advances achieved by research, there is still an intense need to investigate biomarkers for diagnosis, prognosis and that explain the evolution and progression of SGTs.

Methods: We performed a comprehensive literature review of the molecular alterations focusing on the most frequent malignant SGTs: mucoepidermoid carcinoma and adenoid cystic carcinoma.

Results: Due to the importance of biomarkers in the tumorigenenic process, this review aimed to address the mechanisms involved and to describe molecular and biomarker pathways to better understand some aspects of the pathophysiology of salivary gland tumorigenesis.

Conclusions: Molecular analysis is essential not only to improve the diagnosis and prognosis of the tumors but also to identify novel driver pathways in the precision medicine scenario.

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唾液腺黏液表皮样癌和腺样囊性癌的分子方面。

背景：唾液腺肿瘤（SGTs）是一种罕见且高度异质性的病变，因此诊断工作极具挑战性。此外，由于研究和评估样本的数量较少，预后和诊断难以确定。尽管研究取得了长足进步，但仍亟需研究用于诊断、预后以及解释 SGTs 演变和进展的生物标志物：我们对分子改变进行了全面的文献综述，重点是最常见的恶性 SGT：粘液表皮样癌和腺样囊性癌：由于生物标志物在肿瘤发生过程中的重要性，本综述旨在探讨相关机制，描述分子和生物标志物途径，以便更好地理解唾液腺肿瘤发生的病理生理学的某些方面：结论：分子分析不仅对改善肿瘤的诊断和预后至关重要，而且对识别精准医疗中的新型驱动途径也至关重要。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.