Role of Calprotectin, IL-6, and CRP in Distinguishing Between Inflammatory Bowel Disease and Diarrhea Predominant Irritable Bowel Syndrome.

Medical archives (Sarajevo, Bosnia and Herzegovina) Pub Date : 2024-01-01 DOI:10.5455/medarh.2024.78.105-111

Bui-Thi Thu Huong, Nguyen Minh Hien, Nguyen Tien Dung, Dao Minh Quang, Nguyen Thanh Vinh, Tran Thanh Tu, Tran Khanh Chi, Le-Thi Bich Phuong, Nguyen-Thi Nhan

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Abstract

Background: The early establishment of prophylaxis and immediate administration of anticoagulant therapy upon the diagnosis of venous thromboembolism should be the treatment objectives in these patients.

Objective: The study aimed to determine the optimal cut-off point of Calprotectin, IL-6 (interleukin-6), CRP (C reactive protein) to differentiate UC, IBS-D.

Methods: A cross-sectional descriptive study of 335 individuals ≥15 years old was performed, including 31 healthy controls, 215 with IBS-D, 71 diagnosed with UC, and 18 diagnosed with CD. Receiver Operating Characteristics (ROC), sensitivity, specificity, and area under curve (AUC) were computed.

Results: The results showed that the median value of calprotectin (IQR) in healthy participants was 20.0 (6.0 - 34.0) µg/g; 17,7 (8,7-38,9) µg/g in IBS-D group; 1710.0 (588 - 4260,0) µg/g in UC group; and 560.5 (177.8 - 1210.0) µg/g in CD group. Calprotectin concentration in IBD group including UC and CD was higher than IBS-D with p<0.05. The median value of CRP (range IQR) was 1,3 (0,9 - 2,3) mg/L in IBS-D group; 7.0 (2.4 -16.6) mg/L in UC group; and 10.1 (2.2 - 42.5) mg/L in CD group. CRP concentration in IBD group including UC and CD was higher than IBS-D with p<0.05. The median value of IL-6 (range IQR) was 2.3 (1.6 - 5.7) pg/mL in IBS-D group; 16.8 (9.4 - 47.0) pg/mL in UC group; and 9.4 (7.9 - 11.0) pg/mL in CD group. Calprotectin concentration in IBD group including UC and CD was higher than IBS-D with p<0.05. The optimal cut-off point of calprotectin that differentiated IBS-D from IBD was 110.5 µg/g, with sensitivity and specificity of 93.3% and 91.4%, respectively; of IL-6 was 7.2 pg/mL with sensitivity and specificity of 92.0% and 78.0%, respectively; of CRP of 2.4 mg/L had specific sensitivities of 83.3% and 86.0%, respectively.

Conclusion: The Calprotectin immunoassay has the best value in discriminating between IBD and IBS-D.

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钙蛋白、IL-6 和 CRP 在区分炎症性肠病和以腹泻为主的肠易激综合征中的作用

背景：静脉血栓栓塞症患者的治疗目标应该是尽早建立预防措施并在确诊后立即进行抗凝治疗：该研究旨在确定钙蛋白、IL-6（白细胞介素-6）和CRP（C反应蛋白）的最佳临界点，以区分UC和IBS-D：方法：对335名年龄≥15岁的患者进行了横断面描述性研究，其中包括31名健康对照者、215名IBS-D患者、71名确诊为UC的患者和18名确诊为CD的患者。研究人员计算了受试者操作特征（ROC）、灵敏度、特异性和曲线下面积（AUC）：结果显示：健康参与者的钙黏蛋白中位值（IQR）为 20.0（6.0 - 34.0）微克/克；IBS-D 组为 17.7（8.7 - 38.9）微克/克；UC 组为 1710.0（588 - 4260.0）微克/克；CD 组为 560.5（177.8 - 1210.0）微克/克。包括 UC 和 CD 在内的 IBD 组的钙粘蛋白浓度高于 IBS-D（pC）：钙蛋白免疫测定在鉴别 IBD 和 IBS-D 方面具有最佳价值。

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Medical archives (Sarajevo, Bosnia and Herzegovina)

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