ATP binding to Nerve Growth Factor (NGF) and pro-Nerve Growth Factor (proNGF): an endogenous molecular switch modulating neurotrophins activity.

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Society transactions Pub Date : 2024-06-26 DOI:10.1042/BST20231089
Francesca Paoletti
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Abstract

ATP has recently been reconsidered as a molecule with functional properties which go beyond its recognized role of the energetic driver of the cell. ATP has been described as an allosteric modulator as well as a biological hydrotrope with anti-aggregation properties in the crowded cellular environment. The role of ATP as a modulator of the homeostasis of the neurotrophins (NTs), a growth factor protein family whose most known member is the nerve growth factor (NGF), has been investigated. The modulation of NTs by small endogenous ligands is still a scarcely described area, with few papers reporting on the topic, and very few reports on the molecular determinants of these interactions. However, a detailed atomistic description of the NTs interaction landscape is of urgent need, aiming at the identification of novel molecules as potential therapeutics and considering the wide range of potential pharmacological applications for NGF and its family members. This mini-review will focus on the unique cartography casting the interactions of the endogenous ligand ATP, in the interaction with NGF as well as with its precursor proNGF. These interactions revealed interesting features of the ATP binding and distinct differences in the binding mode between the highly structured mature NGF and its precursor, proNGF, which is characterized by an intrinsically unstructured domain. The overview on the recent available data will be presented, together with the future perspectives on the field.

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神经生长因子(NGF)和原神经生长因子(proNGF)的 ATP 结合:调节神经营养素活性的内源性分子开关。
最近,人们重新考虑了 ATP 分子的功能特性,这种特性超出了其作为细胞能量驱动力的公认作用。ATP 被描述为一种异位调节剂,同时也是一种在拥挤的细胞环境中具有抗聚集特性的生物水凝胶。神经生长因子(NTs)是一种生长因子蛋白家族,其最著名的成员是神经生长因子(NGF)。小的内源性配体对 NTs 的调节作用仍然是一个鲜有描述的领域,有关这一主题的论文很少,而有关这些相互作用的分子决定因素的报道也寥寥无几。然而,考虑到 NGF 及其家族成员具有广泛的潜在药理应用,急需对 NTs 的相互作用进行详细的原子学描述,以确定作为潜在疗法的新型分子。这篇微型综述将重点介绍内源性配体 ATP 与 NGF 及其前体 proNGF 相互作用的独特制图。这些相互作用揭示了 ATP 结合的有趣特征,以及高度结构化的成熟 NGF 与其前体 proNGF 之间结合模式的明显差异。报告将概述最新的可用数据,并展望该领域的未来前景。
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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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