The Genetic Variants of Long Noncoding RNA MEG3 and Its Association to the Clinical Features of Diabetic Retinopathy.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY Current Eye Research Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI:10.1080/02713683.2024.2350590

Hsiang-Wen Chien, Kai Wang, Shih-Chun Chao, Chia-Yi Lee, Hung-Yu Lin, Shun-Fa Yang

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Abstract

Purpose: This study aimed to investigate the potential correlation between the single-nucleotide polymorphism (SNP) of maternally expressed gene 3 (MEG3) and the clinical manifestations of diabetic retinopathy (DR).

Methods: Five loci of MEG3 SNPs including rs4081134 (G/A), rs10144253 (T/C), rs7158663 (G/A), rs3087918 (T/G) and rs11160608 (A/C) were genotyped by TaqMan allelic discrimination in 457 non-DR patients and 280 DR individuals.

Results: The distribution frequency of MEG3 SNP rs7158663 GA (AOR: 0.683, 95% CI: 0.478-0.975, p = 0.036) and MEG3 SNP rs7158663 GA + AA (AOR: 0.686, 95% CI: 0.487-0.968, p = 0.032) were significantly lower in the DR group. And the MEG3 SNP rs7158663 GA + AA (AOR: 0.610, 95% CI: 0.377-0.985, p = 0.043) demonstrated a significantly lower distribution frequency in the male DR group. Besides, the DR patients with MEG3 SNP rs7158663 GA + AA genotype showed a significantly lower HbA1c level than the DR patients with MEG3 SNP rs7158663 GG genotype (7.29 ± 1.23 versus 7.74 ± 1.49, p = 0.013). Moreover, in the analysis using data from gene expression data series database, a higher MEG3 level was significantly correlated to a lower miR-182 level in the database (p = 0.0114).

Conclusions: In this study, the distribution frequency of MEG3 SNP rs7158663 GA + AA genotype was lower in DR, while the DR would develop under lower HbA1c level in DM patients with this MEG3 SNP variant.

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长非编码 RNA MEG3 的遗传变异及其与糖尿病视网膜病变临床特征的关系

目的：本研究旨在探讨母体表达基因3（MEG3）单核苷酸多态性（SNP）与糖尿病视网膜病变（DR）临床表现之间的潜在相关性：方法：对457例非DR患者和280例DR患者的MEG3 SNP进行TaqMan等位基因分型，包括rs4081134 (G/A)、rs10144253 (T/C)、rs7158663 (G/A)、rs3087918 (T/G)和rs11160608 (A/C)：结果：MEG3 SNP rs7158663 GA (AOR: 0.683, 95% CI: 0.478-0.975, p = 0.036)和MEG3 SNP rs7158663 GA + AA (AOR: 0.686, 95% CI: 0.487-0.968, p = 0.032)的分布频率在DR组中显著降低。而MEG3 SNP rs7158663 GA + AA（AOR：0.610，95% CI：0.377-0.985，p = 0.043）在男性DR组中的分布频率明显较低。此外，MEG3 SNP rs7158663 GA + AA 基因型的 DR 患者的 HbA1c 水平明显低于 MEG3 SNP rs7158663 GG 基因型的 DR 患者（7.29 ± 1.23 对 7.74 ± 1.49，P = 0.013）。此外，在使用基因表达数据系列数据库的数据进行分析时，数据库中较高的MEG3水平与较低的miR-182水平显著相关（p = 0.0114）：结论：在本研究中，MEG3 SNP rs7158663 GA + AA 基因型在DR中的分布频率较低，而在具有该MEG3 SNP变异的DM患者中，DR会在较低的HbA1c水平下发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.