Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-08 DOI:10.1007/s12265-024-10517-7

Tianshuo Yang, Zirui Liu, Songren Shu, Zhice Chen, Xiumeng Hua, Jiangping Song

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Abstract

In modern cardiovascular research, isolated perfused hearts have become cost-effective and highly reproducible tools to investigate the mechanisms of cardiovascular diseases (CVDs). Since they were first introduced in the nineteenth century, isolated perfused hearts have been extensively used for testing novel therapies, elucidating cardiac metabolic and electrophysiological activities, and modeling CVDs, including ischemic heart disease, arrhythmias, and hyperacute rejection. In recent years, ex vivo heart perfusion (EVHP) has shown potential in cardiac transplantation by allowing prolonged preservation and reconditioning of donor hearts. In this review, we summarize the evolution of the isolated perfused heart technique and its applications in cardiovascular research to help researchers comprehensively understand the capabilities of isolated heart models and provide guidance to use them to investigate various CVDs.

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用于心血管研究的离体灌注心：老狗出新招

在现代心血管研究中，离体灌注心脏已成为研究心血管疾病（CVDs）机制的成本效益高、可重复性强的工具。自十九世纪首次引入以来，离体灌注心脏已被广泛用于测试新型疗法、阐明心脏代谢和电生理活动，以及建立包括缺血性心脏病、心律失常和急性排斥反应在内的心血管疾病模型。近年来，体外心脏灌注（EVHP）通过延长供体心脏的保存和修复时间，显示出在心脏移植中的潜力。在这篇综述中，我们总结了离体心脏灌注技术的演变及其在心血管研究中的应用，以帮助研究人员全面了解离体心脏模型的功能，并为使用它们研究各种心血管疾病提供指导。

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.