Histological analysis of laser-enabled tissue coring with a novel 2910 nm erbium-doped fluoride glass fiber laser

IF 2.2 3区 医学 Q2 DERMATOLOGY Lasers in Surgery and Medicine Pub Date : 2024-05-08 DOI:10.1002/lsm.23792
Taryn N. Murray MD, Hasina Maredia MD, Paul M. Friedman MD
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Abstract

Objectives

There remains an unmet need for a laser-enabled tissue coring device that can effectively improve face and neck skin laxity and rhytides. We investigate a novel 2910 nm erbium-doped fluoride glass fiber laser (2910 nm fiber laser) (UltraClear; Acclaro Medical) for laser-coring of submental tissue.

Methods

Five subjects, Glogau scale III−IV, were treated with a single pulse of the laser-coring mode of the 2910 nm fiber laser in the submentum. A 4 mm punch biopsy was immediately performed. Biopsy specimens were sectioned and stained with hematoxylin and eosin and placed on glass slides. All sections were reviewed, and sections containing the center of the transected core were analyzed for depth and diameter of the ablative microchannel and width of the surrounding zone of coagulation.

Results

A total of 15 intact micro-cores were analyzed. Histological analysis revealed an average ± standard deviation microchannel diameter of 242.5 ± 65.2 µm, an average ablative depth of 980 ± 318.8 µm, and an average zone of coagulation of 104 ± 32 µm.

Conclusions

Laser-enabled tissue coring with a novel 2910 nm fiber laser can safely achieve a wider microchannel diameter with ablative depth extending to the mid and deep dermis, which has the potential for collagen contraction and tissue tightening. Laser-coring to this ablation diameter and depth and with the surrounding zone of coagulation was found to be safe without adverse effects of post-inflammatory erythema or scarring in our study.

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利用新型 2910 纳米掺铒氟化玻璃光纤激光器对激光辅助组织取芯进行组织学分析。
目标:目前仍未满足对可有效改善面颈部皮肤松弛和皱纹的激光组织切削设备的需求。我们研究了一种新型 2910 nm 掺铒氟化玻璃光纤激光器(2910 nm 光纤激光器)(UltraClear;Acclaro Medical),用于对下颌组织进行激光切削:方法:对五名格洛高分级 III-IV 级的受试者进行了治疗,采用 2910 nm 光纤激光器的单脉冲激光凿毛模式对其进行治疗。随即进行 4 毫米打孔活检。活检样本经切片、苏木精和伊红染色后置于玻璃载玻片上。对所有切片进行复查,并对包含横切核心中心的切片进行分析,以确定烧蚀微通道的深度和直径以及周围凝固区的宽度:结果:共分析了 15 个完整的微芯。组织学分析显示,微通道的平均直径为 242.5 ± 65.2 µm,平均烧蚀深度为 980 ± 318.8 µm,平均凝固区为 104 ± 32 µm:结论:使用新型 2910 nm 光纤激光器进行激光组织抽芯,可以安全地获得更宽的微通道直径,烧蚀深度可延伸至真皮中层和深层,具有收缩胶原和紧致组织的潜力。在我们的研究中发现,按照这种烧蚀直径和深度以及周围的凝固区进行激光切削是安全的,不会产生炎症后红斑或瘢痕等不良影响。
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来源期刊
CiteScore
5.40
自引率
12.50%
发文量
119
审稿时长
1 months
期刊介绍: Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.
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