ANRIL: A Long Noncoding RNA in Age-related Diseases.

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-04-22 DOI:10.2174/0113895575295976240415045602

Rui Wang, Qi Yuan, Yuan Wen, Yifan Zhang, Yaqi Hu, Shuwen Wang, Chengfu Yuan

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Abstract

The intensification of the aging population is often accompanied by an increase in agerelated diseases, which impair the quality of life of the elderly. The characteristic feature of aging is progressive physiological decline, which is the largest cause of human pathology and death worldwide. However, natural aging interacts in exceptionally complex ways within and between organs, but its underlying mechanisms are still poorly understood. Long non-coding RNA (lncRNA) is a type of noncoding RNA that exceeds 200 nucleotides in length and does not possess protein-coding ability. It plays a crucial role in the occurrence and development of diseases. ANRIL, also known as CDKN2B-AS1, is an antisense ncRNA located at the INK4 site. It can play a crucial role in agerelated disease progression by regulating single nucleotide polymorphism, histone modifications, or post-transcriptional modifications (such as RNA stability and microRNA), such as cardiovascular disease, diabetes, tumor, arthritis, and osteoporosis. Therefore, a deeper understanding of the molecular mechanisms of lncRNA ANRIL in age-related diseases will help provide new diagnostic and therapeutic targets for clinical practice.

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ANRIL：与老年疾病相关的长非编码 RNA。

人口老龄化的加剧往往伴随着老年疾病的增加，这些疾病损害了老年人的生活质量。衰老的特征是生理机能的逐渐衰退，这是全世界人类病变和死亡的最大原因。然而，自然衰老在器官内部和器官之间以异常复杂的方式相互作用，但人们对其潜在机制仍知之甚少。长非编码 RNA（lncRNA）是一种长度超过 200 个核苷酸的非编码 RNA，不具有编码蛋白质的能力。它在疾病的发生和发展中起着至关重要的作用。ANRIL 又称 CDKN2B-AS1，是位于 INK4 位点的反义 ncRNA。它可以通过调控单核苷酸多态性、组蛋白修饰或转录后修饰（如 RNA 稳定性和 microRNA），在心血管疾病、糖尿病、肿瘤、关节炎和骨质疏松症等与年龄有关的疾病进展中发挥关键作用。因此，深入了解 lncRNA ANRIL 在老年相关疾病中的分子机制将有助于为临床实践提供新的诊断和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.