Efficacy and safety of PD-1/PD-L1 inhibitors in elderly patients with advanced non-small cell lung cancer

IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Clinical Respiratory Journal Pub Date : 2024-05-08 DOI:10.1111/crj.13763
Li Li, Chunhua Xu, Wei Wang, Qian Zhang
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Abstract

Objective

This study aimed to investigate the efficacy and safety of PD-1/PD-L1 inhibitors in treatment of elderly patients with advanced non-small cell lung cancer (NSCLC).

Methods

Patients with advanced NSCLC ≥70 years old who received PD-1/PD-L1 inhibitors in our hospital were retrospectively analyzed. According to age, the patient were stratified as follows: 70–75 years old, 76–80 years old, and >80 years old. Kaplan–Meier method was used for survival analysis, and univariate and multivariate Cox proportional hazards regression models were used to analyze the correlation between different clinical characteristics and survival.

Results

A total of 58 elderly patients with advanced non-small cell cancer were enrolled in this study. Patients aged 70–75, 76–80, and >80 years old were 32, 19, and 7, respectively. For the all, median OS was 17.0 months, and PFS was 7.0 months. PFS and OS did not differ according to age (P = 0.396, 0.054, respectively). Univariate analysis showed that PS of 0–1, stage III, first-line therapy and irAEs were associated with longer PFS, and PS of 0–1, stage III, and first-line therapy were associated with longer OS. Multivariate analysis showed that patients with stage III had longer PFS. PFS and OS of patients with PS ≥ 2 were significantly shorter than those of patients with PS of 0–1.

Conclusions

In the present real-world retrospective cohort, PD-1/PD-L1 inhibitors are effective and well tolerated in elderly patients with advanced NSCLC. Immunotherapy should be actively used as early as possible in older patients advanced NSCLC.

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PD-1/PD-L1抑制剂在老年晚期非小细胞肺癌患者中的疗效和安全性。
研究目的本研究旨在探讨PD-1/PD-L1抑制剂治疗老年晚期非小细胞肺癌(NSCLC)患者的有效性和安全性:回顾性分析在我院接受PD-1/PD-L1抑制剂治疗的年龄≥70岁的晚期NSCLC患者。根据年龄对患者进行分层如下:70-75岁、76-80岁和>80岁。采用 Kaplan-Meier 法进行生存率分析,并采用单变量和多变量 Cox 比例危险回归模型分析不同临床特征与生存率之间的相关性:本研究共纳入了 58 名老年晚期非小细胞癌患者。年龄在70-75岁、76-80岁和80岁以上的患者分别有32人、19人和7人。所有患者的中位 OS 为 17.0 个月,PFS 为 7.0 个月。PFS和OS与年龄无关(分别为0.396和0.054)。单变量分析显示,PS为0-1、III期、一线治疗和irAEs与较长的PFS相关,而PS为0-1、III期和一线治疗与较长的OS相关。多变量分析显示,III期患者的PFS更长。PS≥2患者的PFS和OS明显短于PS为0-1的患者:在本真实世界回顾性队列中,PD-1/PD-L1抑制剂对老年晚期NSCLC患者有效且耐受性良好。老年晚期NSCLC患者应尽早积极使用免疫疗法。
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来源期刊
Clinical Respiratory Journal
Clinical Respiratory Journal 医学-呼吸系统
CiteScore
3.70
自引率
0.00%
发文量
104
审稿时长
>12 weeks
期刊介绍: Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)
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