GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma

IF 1.9 4区医学 Q3 RESPIRATORY SYSTEM Clinical Respiratory Journal Pub Date : 2024-05-07 DOI:10.1111/crj.13757

Guanqiang Yan, Guosheng Li, Xiang Gao, Jun Liu, Yue Li, Jingxiao Li, Huafu Zhou

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Abstract

Objective

This research was aimed to comprehensively investigate the expression levels, diagnostic and prognostic implications, and the relationship with immune infiltration of G2 and S phase-expressed-1 (GTSE1) across 33 tumor types, including lung adenocarcinoma (LUAD), through gene expression profiling.

Methods

GTSE1 mRNA expression data together with clinical information were acquired from Xena database of The Cancer Genome Atlas (TCGA), ArrayExpress, and Gene Expression Omnibus (GEO) database for this study. The Wilcoxon rank-sum test was used to detect differences in GTSE1 expression between groups. The ability of GTSE1 to accurately predict cancer status was evaluated by calculating the area under the curve (AUC) value for the receiver operating characteristic curve. Additionally, we investigated the predictive value of GTSE1 in individuals diagnosed with neoplasms using univariate Cox regression analysis as well as Kaplan–Meier curves. Furthermore, the correlation between GTSE1 expression and levels of immune infiltration was assessed by utilizing the Tumor Immune Estimate Resource (TIMER) database to calculate the Spearman rank correlation coefficient. Finally, the pan-cancer analysis findings were validated by examining the association between GTSE1 expression and prognosis among patients with LUAD.

Results

GTSE1 exhibited significantly increased expression levels in a wide range of tumor tissues in contrast with normal tissues (p < 0.05). The expression of GTSE1 in various tumors was associated with clinical features, overall survival, and disease-specific survival (p < 0.05). In immune infiltration analyses, a strong correlation of the level of immune infiltration with the expression of GTSE1 was observed. Furthermore, GTSE1 demonstrated good discriminative and diagnostic value for most tumors. Additional experiments confirmed the relationship between elevated GTSE1 expression and unfavorable prognosis in individuals diagnosed with LUAD. These findings indicated the crucial role of GTSE1 expression level in influencing the development and immune infiltration of different types of tumors.

Conclusions

GTSE1 might be a potential biomarker for the prognosis of pan-cancer. Meanwhile, it represented a promising target for immunotherapy.

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GTSE1：包括肺腺癌在内的多种肿瘤的潜在预后和诊断生物标记物。

研究目的本研究旨在通过基因表达谱分析，全面研究包括肺腺癌（LUAD）在内的33种肿瘤类型中G2和S期表达-1（GTSE1）的表达水平、诊断和预后意义以及与免疫浸润的关系：本研究从癌症基因组图谱（TCGA）的Xena数据库、ArrayExpress和Gene Expression Omnibus（GEO）数据库中获取了GTSE1 mRNA表达数据和临床信息。本研究采用 Wilcoxon 秩和检验检测组间 GTSE1 表达的差异。通过计算接收者操作特征曲线的曲线下面积（AUC）值，评估了GTSE1准确预测癌症状态的能力。此外，我们还利用单变量 Cox 回归分析和 Kaplan-Meier 曲线研究了 GTSE1 对确诊肿瘤患者的预测价值。此外，通过利用肿瘤免疫估算资源（TIMER）数据库计算斯皮尔曼等级相关系数，评估了 GTSE1 表达与免疫浸润水平之间的相关性。最后，通过研究GTSE1表达与LUAD患者预后之间的关系，验证了泛癌症分析结果：结果：与正常组织相比，GTSE1在多种肿瘤组织中的表达水平均明显升高（p 结论：GTSE1可能是一种潜在的肿瘤标志物：GTSE1可能是泛癌症预后的潜在生物标志物。同时，它也是免疫疗法的一个有前途的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)