The Application of Berberine in Fibrosis and the Related Diseases.

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-05-08 DOI:10.1142/S0192415X24500307
Rongmao Gao, Yuanyu Lu, Wei Zhang, Zhao Zhang
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Abstract

The formation of fibrotic tissue, characterized by the excessive accumulation of extracellular matrix (ECM) components such as collagen and fibronectin, is a normal and crucial stage of tissue repair in all organs. The over-synthesis, deposition, and remodeling of ECM components lead to organ dysfunction, posing a significant medical burden. Berberine, an isoquinoline alkaloid, is commonly used in the treatment of gastrointestinal diseases. With the deepening of scientific research, it has been gradually discovered that berberine also plays an important role in fibrotic diseases. In this review, we systematically introduce the effective role of berberine in fibrosis-related diseases. Specifically, this paper aims to provide a comprehensive review of the therapeutic role of berberine in treating fibrosis in organs such as the heart, liver, lungs, and kidneys. By summarizing its various pathways and mechanisms of action, including the inhibition of the transforming growth factor-[Formula: see text]/Smad signaling pathway, PI3K/Akt signaling pathway, MAPK signaling pathway, RhoA/ROCK signaling, and mTOR/p70S6K signaling pathway, as well as its activation of the Nrf2-ARE signaling pathway, AMPK signaling pathway, phosphorylated Smad 2/3 and Smad 7, and other signaling pathways, this review offers additional evidence to support the treatment of fibrotic diseases.

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小檗碱在纤维化及相关疾病中的应用。
纤维化组织的形成以细胞外基质(ECM)成分(如胶原蛋白和纤连蛋白)的过度积累为特征,是所有器官组织修复的正常和关键阶段。ECM 成分的过度合成、沉积和重塑会导致器官功能障碍,造成严重的医疗负担。小檗碱是一种异喹啉生物碱,常用于治疗胃肠道疾病。随着科学研究的深入,人们逐渐发现小檗碱在纤维化疾病中也发挥着重要作用。在这篇综述中,我们系统地介绍了小檗碱在纤维化相关疾病中的有效作用。具体而言,本文旨在全面综述小檗碱在治疗心、肝、肺和肾等器官纤维化方面的治疗作用。通过总结小檗碱的各种作用途径和机制,包括抑制转化生长因子-[Formula:见正文]/Smad 信号通路、PI3K/Akt 信号通路、MAPK 信号通路、RhoA/ROCK 信号通路和 mTOR/p70S6K 信号通路,以及它对 Nrf2-ARE 信号通路、AMPK 信号通路、磷酸化 Smad 2/3 和 Smad 7 以及其他信号通路的激活作用,本综述为纤维化疾病的治疗提供了更多的证据支持。
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