Retrieval action of zinc and folic acid for the restoration of normal reproductive function in bisphenol-A exposed male albino mice.

IF 0.6 4区 农林科学 Q3 VETERINARY SCIENCES Veterinarni Medicina Pub Date : 2022-06-08 eCollection Date: 2022-06-01 DOI:10.17221/13/2022-VETMED
Afrina Mustari, Mahabub Alam, Mohammad Alam Miah, Mohammed Nooruzzaman, Khaled Mahmud Sujan, Emdadul Hauqe Chowdhury
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Abstract

Bisphenol-A (BPA) has become a great concern due to its toxic effects. The present study investigated the retrieval action of zinc (Zn) and folic acid (FA) supplementation against BPA-induced reproductive toxicities in male albino mice. A total of seventy-five 25-28 day-old mice were divided into five equal groups (group A-E, 15 mice in each group). The mice were given normal rations (control, group A) or administered with daily doses of BPA at 50 mg/kg body weight (b.w.) (group B-E). The mice from groups C, D and E were supplemented with Zn (10 mg/kg b.w.), FA (3 mg/kg b.w.) and both in the feed, respectively, daily for 12 weeks. Blood samples were collected, and the sera were separated for biochemical and hormonal analyses. The standard method was followed to test the sperm motility and sperm count. The testis samples were processed for a routine histopathological study using haematoxylin and eosin staining. The sperm counts, motility, and serum testosterone significantly declined in the BPA-exposed animals, but dramatically increased after the Zn and FA supplementation. There was significant degeneration of the seminiferous tubules in the testes of the BPA-exposed mice, which was recovered moderately by the Zn and FA supplementation. The study shows the retrieval action of zinc and folic acid in the restoration of normal reproductive function in bisphenol-A exposed male mice.

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锌和叶酸对暴露于双酚 A 的雄性白化小鼠恢复正常生殖功能的修复作用。
双酚 A(BPA)因其毒性作用而备受关注。本研究调查了补充锌(Zn)和叶酸(FA)对雄性白化小鼠因双酚 A 引起的生殖毒性的恢复作用。研究人员将 75 只 25-28 天大的小鼠分成 5 组(A-E 组,每组 15 只)。给小鼠提供正常口粮(对照组,A 组),或给小鼠每天注射 50 毫克/千克体重(b.w.)的双酚 A(B-E 组)。C 组、D 组和 E 组小鼠每天分别在饲料中添加锌(10 毫克/千克体重)、脂肪酸(3 毫克/千克体重)或两者,持续 12 周。采集血样,分离血清进行生化和激素分析。按照标准方法检测精子活力和精子数量。睾丸样本经处理后,使用血红素和伊红染色法进行常规组织病理学研究。暴露于双酚 A 的动物的精子数量、活力和血清睾酮显著下降,但在补充锌和脂肪酸后,精子数量、活力和血清睾酮急剧上升。暴露于双酚 A 的小鼠睾丸中的曲细精管出现了明显的退化,而补充锌和脂肪酸后,曲细精管得到了适度的恢复。这项研究表明,锌和叶酸在恢复暴露于双酚 A 的雄性小鼠的正常生殖功能方面具有恢复作用。
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来源期刊
Veterinarni Medicina
Veterinarni Medicina Veterinary Sciences-兽医学
CiteScore
1.30
自引率
0.00%
发文量
62
审稿时长
18-36 weeks
期刊介绍: The journal Veterinarni Medicina publishes in English original papers, short communications, critical reviews and case reports from all fields of veterinary and biomedical sciences.
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