A Case of Multiple Myeloma with Atypical Cutaneous Presentation Treated by Daratumumab + CYBORG

IF 1.6 Q3 HEMATOLOGY Hematology, Transfusion and Cell Therapy Pub Date : 2024-05-01 Epub Date: 2024-05-07 DOI:10.1016/j.htct.2024.04.017

Bengisu Ece DUMAN , Candas MUMCU , Berra Nur ISCI , Emre BAL , Meryem SENER , Hande Yanar , Arbil ACIKALIN , Birol GUVENC

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Abstract

This case report illustrates the unconventional progression of multiple myeloma (MM) in a 57-year-old male, primarily highlighted by a cutaneous manifestation on the right cheek malar region, indicative of disease recurrence. Initially diagnosed following back pain and dyspnea, the patient's journey took a distinctive path from standard multiple myeloma treatments to the innovative application of daratumumab + CYBORG therapy. The biopsy from the lesion confirmed the recurrence of plasma cell neoplasia, leading to the adoption of daratumumab + CYBORG therapy. This innovative treatment strategy underscores the evolving landscape of MM management, particularly in cases presenting with atypical symptoms such as cutaneous involvement. The implementation of daratumumab + CYBORG therapy in this context not only highlights its potential as a significant advancement in MM treatment.

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达拉单抗+CYBORG治疗伴有非典型皮肤表现的多发性骨髓瘤病例

本病例报告展示了一名 57 岁男性多发性骨髓瘤（MM）的非常规进展，主要突出表现为右颊颊区的皮肤表现，表明疾病复发。患者最初因背部疼痛和呼吸困难而被确诊，从标准的多发性骨髓瘤治疗到达拉单抗+CYBORG疗法的创新应用，患者的病程经历了一条与众不同的道路。病灶活检证实浆细胞瘤复发，因此采用了达拉单抗+CYBORG疗法。这一创新治疗策略凸显了 MM 治疗的不断发展，尤其是在出现皮肤受累等非典型症状的病例中。在这种情况下采用达拉单抗+CYBORG疗法，不仅凸显了其作为MM治疗领域重大进展的潜力，而且还为MM患者提供了一种新的治疗方法。

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