Histone deacetylase 6 as a novel promising target to treat cardiovascular disease

Cancer Innovation Pub Date : 2024-05-07 DOI:10.1002/cai2.114
Ya-Xi Wu, Bing-Qian Li, Xiao-Qian Yu, Yu-Lin Liu, Rui-Hao Chui, Kai Sun, Dian-Guang Geng, Li-Ying Ma
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Abstract

Histone deacetylase 6 (HDAC6) belongs to a class of epigenetic targets that have been found to be a key protein in the association between tumors and cardiovascular disease. Recent studies have focused on the crucial role of HDAC6 in regulating cardiovascular diseases such as atherosclerosis, myocardial infarction, myocardial hypertrophy, myocardial fibrosis, hypertension, pulmonary hypertension, and arrhythmia. Here, we review the association between HDAC6 and cardiovascular disease, the research progress of HDAC6 inhibitors in the treatment of cardiovascular disease, and discuss the feasibility of combining HDAC6 inhibitors with other therapeutic agents to treat cardiovascular disease.

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组蛋白去乙酰化酶 6 是一种治疗心血管疾病的新型有望靶点
组蛋白去乙酰化酶 6(HDAC6)属于一类表观遗传靶标,已被发现是肿瘤与心血管疾病相关的关键蛋白。最近的研究集中于 HDAC6 在调控动脉粥样硬化、心肌梗塞、心肌肥厚、心肌纤维化、高血压、肺动脉高压和心律失常等心血管疾病中的关键作用。在此,我们回顾了 HDAC6 与心血管疾病的关系、HDAC6 抑制剂治疗心血管疾病的研究进展,并探讨了 HDAC6 抑制剂与其他治疗药物联合治疗心血管疾病的可行性。
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