{"title":"Mechanism of Action of the Low-Frequency Electromagnetic Field on Aqueous Solutions of Biopolymers","authors":"E. E. Tekutskaya, G. P. Ilchenko, M. G. Baryshev","doi":"10.1134/s0006350923050299","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This paper presents the transformation mechanism of a signal from the magnetic component of a low-frequency electromagnetic field with extremely low energy into a chemical and biochemical response in aqueous solutions of nucleic acids and proteins. The developed theoretical model shows that oxidative DNA damage and conformational transitions in proteins are based on a universal mechanism for changing the amount of the most long-lived form, hydrogen peroxide, in a chemical oscillator of mutual transformations of reactive oxygen species under a low-intensity electromagnetic field. It has been experimentally found that the content of hydrogen peroxide in solutions of biopolymers resonantly depends on the frequency of the applied field. Conformational changes in proteins are accompanied by increasing accessibility and activity of the nucleophilic centers, which are potential targets for reactive oxygen species. Complete unfolding and denaturation of the protein amino-acid chain in a low-frequency electromagnetic field did not occur. It has been shown that the enhanced formation of hydrogen peroxide at 3 and 50 Hz leads to oxidative modification of nitrogenous bases in DNA.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":null,"pages":null},"PeriodicalIF":4.0330,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://doi.org/10.1134/s0006350923050299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
This paper presents the transformation mechanism of a signal from the magnetic component of a low-frequency electromagnetic field with extremely low energy into a chemical and biochemical response in aqueous solutions of nucleic acids and proteins. The developed theoretical model shows that oxidative DNA damage and conformational transitions in proteins are based on a universal mechanism for changing the amount of the most long-lived form, hydrogen peroxide, in a chemical oscillator of mutual transformations of reactive oxygen species under a low-intensity electromagnetic field. It has been experimentally found that the content of hydrogen peroxide in solutions of biopolymers resonantly depends on the frequency of the applied field. Conformational changes in proteins are accompanied by increasing accessibility and activity of the nucleophilic centers, which are potential targets for reactive oxygen species. Complete unfolding and denaturation of the protein amino-acid chain in a low-frequency electromagnetic field did not occur. It has been shown that the enhanced formation of hydrogen peroxide at 3 and 50 Hz leads to oxidative modification of nitrogenous bases in DNA.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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