A. V. Orlov, Yu. A. Malkerov, A. M. Skirda, D. O. Novichikhin, S. L. Znoyko, V. A. Bragina, P. I. Nikitin
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引用次数: 0
Abstract
Magnetic particles based on superparamagnetic iron oxide nanocrystals find increasing application in the development of modern techniques for high-precision express determination of biomolecule concentrations. In this work, based on an original technique for the ultrasensitive detection of nonlinear magnetic nanomaterials, we develop a universal method for the use of magnetic particles as polyfunctional agents that simultaneously perform several different functions in a single assay for topical tasks of biochemical and medical diagnostics. The method is tested for the rapid quantitative detection of cardiac markers and SARS-CoV-2-associated molecular markers in complex matrices. The proposed method is promising for creating test systems for prehospital monitoring, in particular, emergency molecular diagnostics in patients with a suspected acute myocardial infarction, and the rapid detection of the coronavirus infection.
期刊介绍：
Doklady Physics is a journal that publishes new research in physics of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.
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