M. D. Galkov, A. M. Surin, O. Yu. Lisina, L. R. Gorbacheva
{"title":"Neurodegeneration and Neuroinflammation: The Role of Pannexin 1","authors":"M. D. Galkov, A. M. Surin, O. Yu. Lisina, L. R. Gorbacheva","doi":"10.1134/s181971242305001x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract—</h3><p>Pannexins are capable of forming in the cell membrane anion channels with relatively low conductivity, as well as channels with high nonspecific conductivity that can transport from the cytoplasm into the extracellular space not only inorganic ions but also low molecular weight metabolites with a molecular weight below 1 kDa, in particular ATP, glutamate, glutathione and others. Due to substantial differences in specificity and conductivity, pannexins are involved both in the normal physiological regulation of body functions and in a variety of pathological processes. The review examines the role of pannexin 1 (Panx1) in the occurrence and progression of pathologies of the central nervous system such as ischemia, Parkinson’s and Alzheimer’s diseases, and neuropathic pain. Blockade of Panx1 diminishes the negative consequences of pathological processes, indicating that Panx1 channels may be a promising therapeutic target for the pharmacological correction of brain disorders.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1134/s181971242305001x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract—
Pannexins are capable of forming in the cell membrane anion channels with relatively low conductivity, as well as channels with high nonspecific conductivity that can transport from the cytoplasm into the extracellular space not only inorganic ions but also low molecular weight metabolites with a molecular weight below 1 kDa, in particular ATP, glutamate, glutathione and others. Due to substantial differences in specificity and conductivity, pannexins are involved both in the normal physiological regulation of body functions and in a variety of pathological processes. The review examines the role of pannexin 1 (Panx1) in the occurrence and progression of pathologies of the central nervous system such as ischemia, Parkinson’s and Alzheimer’s diseases, and neuropathic pain. Blockade of Panx1 diminishes the negative consequences of pathological processes, indicating that Panx1 channels may be a promising therapeutic target for the pharmacological correction of brain disorders.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
