Reference Standards for C-Peptide in Korean Population: A Korean Endocrine Hormone Reference Standard Data Center Study.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-05-09 DOI:10.3803/EnM.2023.1888

Jooyoung Cho, Ho-Chan Cho, Ohk-Hyun Ryu, Hyo-Jeong Kim, Chang Geun Kim, Young Ran Yun, Choon Hee Chung

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Abstract

Backgruound: The Korean Endocrine Hormone Reference Standard Data Center (KEHRS DC) has created reference standards (RSs) for endocrine hormones since 2020. This study is the first of its kind, wherein the KEHRS DC established RSs for serum Cpeptide levels in a healthy Korean population.

Methods: Healthy Korean adults were recruited from May 2021 to September 2023. After excluding participants according to our criteria, serum samples were collected; each participant could then choose between fasting glucose only or fasting glucose plus an oral glucose tolerance test (OGTT). If their sample showed high glucose (≥100 mg/dL) or hemoglobin A1c (HbA1c) (≥5.70%), their C-peptide levels were excluded from analyzing the RSs.

Results: A total of 1,532 participants were recruited; however, only the data of 1,050 participants were analyzed after excluding those whose samples showed hyperglycemia or high HbA1c. Post-30-minute OGTT data from 342 subjects and post-120-minute OGTT data from 351 subjects were used. The means±2 standard deviations and expanded uncertainties of fasting, post-30-minute and 120-minute OGTT C-peptide levels were 1.26±0.82 and 0.34-3.18, 4.74±3.57 and 1.14-8.33, and 4.85±3.58 and 1.25-8.34 ng/mL, respectively. Serum C-peptide levels correlated with obesity, serum glucose levels, and HbA1c levels.

Conclusion: The RSs for serum C-peptide levels established in this study are expected to be useful in both clinical and related fields.

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韩国人群的 C 肽参考标准：韩国内分泌激素参考标准数据中心研究。

背景：韩国内分泌激素参考标准数据中心（KEHRS DC）自2020年起制定了内分泌激素参考标准（RSs）。方法：2021 年 5 月至 2023 年 9 月期间，招募了健康的韩国成年人。在根据我们的标准排除参与者后，采集血清样本；然后，每位参与者可选择只测空腹血糖或空腹血糖加口服葡萄糖耐量试验（OGTT）。如果样本显示高血糖（≥100 mg/dL）或血红蛋白 A1c（HbA1c）（≥5.70%），其 C 肽水平将被排除在 RS 分析之外：共招募了 1,532 名参与者，但在排除样本显示高血糖或高 HbA1c 的参与者后，只分析了 1,050 名参与者的数据。研究使用了 342 名受试者的 30 分钟后 OGTT 数据和 351 名受试者的 120 分钟后 OGTT 数据。空腹、30 分钟后和 120 分钟 OGTT C 肽水平的平均值（±2 个标准差）和扩大的不确定性分别为 1.26±0.82 和 0.34-3.18，4.74±3.57 和 1.14-8.33，以及 4.85±3.58 和 1.25-8.34 纳克/毫升。血清 C 肽水平与肥胖、血清葡萄糖水平和 HbA1c 水平相关：本研究建立的血清 C 肽水平 RSs 预计将在临床和相关领域发挥作用。

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来源期刊

Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.60

自引率

5.90%

发文量

145

审稿时长

24 weeks

期刊介绍： The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).