Sex Differences in the Severity and Progression of Neuropsychiatric Symptoms Across Different Dementia Types.

IF 2.3 Q3 CLINICAL NEUROLOGY Neurology. Clinical practice Pub Date : 2024-06-01 Epub Date: 2024-04-18 DOI:10.1212/CPJ.0000000000200299

Chiara Silvestri, Valentina Almici, Ilenia Libri, Irene Mattioli, Maura Cosseddu, Rosanna Turrone, Jasmine Rivolta, Chiara Grassini, Salvatore Caratozzolo, Antonella Alberici, Alessandra Marengoni, Andrea Pilotto, Barbara Borroni, Alessandro Padovani, Alberto Benussi

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Abstract

Background and objectives: Dementia presents not only differing neuropsychiatric symptoms (NPS) across Alzheimer disease (AD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) but also subjective cognitive decline (SCD). This study examined sex-based variations in NPS severity and progression across these conditions.

Methods: We performed a longitudinal cohort study including 1,068 participants. Hierarchical generalized linear mixed models were used to model NPS as a function of disease severity and biological sex at birth.

Results: Female participants with AD exhibited NPS more frequently than male participants. In FTD, female participants had more frequent delusions, hallucinations, and depression/dysphoria, while male participants had higher instances of agitation/aggression, apathy, disinhibition, and irritability/lability. In DLB, male participants showed higher instances of depression, and female participants more frequently experienced anxiety. In SCD, female participants showed higher nighttime behaviors. The trajectory of NPS significantly differed between sexes.

Discussion: These findings highlight sex-specific NPS impact in different neurodegenerative conditions.

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不同类型痴呆症患者神经精神症状的严重程度和发展过程中的性别差异。

背景和目的：痴呆症不仅在阿尔茨海默病（AD）、额颞叶痴呆（FTD）和路易体痴呆（DLB）中表现出不同的神经精神症状（NPS），而且还表现出主观认知能力下降（SCD）。本研究探讨了这些病症中 NPS 严重程度和进展的性别差异：我们进行了一项纵向队列研究，其中包括 1,068 名参与者。我们使用层次化广义线性混合模型来建立 NPS 与疾病严重程度和出生时生理性别的函数关系模型：结果：女性 AD 患者比男性患者更常表现出 NPS。在 FTD 中，女性患者更经常出现妄想、幻觉和抑郁/精神错乱，而男性患者则更经常出现躁动/攻击、冷漠、抑制和易怒/易怒。在 DLB 中，男性受试者抑郁的比例较高，而女性受试者焦虑的比例较高。在 SCD 中，女性患者的夜间行为较多。不同性别的 NPS 轨迹存在明显差异：这些发现突显了不同性别的 NPS 对不同神经退行性疾病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.