Relationship between fibrosis-4 score and microvascular complications in patients with type 2 diabetes mellitus

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2024-08-01 DOI:10.1016/j.ajg.2024.04.001
{"title":"Relationship between fibrosis-4 score and microvascular complications in patients with type 2 diabetes mellitus","authors":"","doi":"10.1016/j.ajg.2024.04.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and study aims</h3><p><span>Nonalcoholic fatty liver disease is the most prevalent </span>chronic liver disease<span><span><span> globally and is linked to augmented susceptibility to type 2 diabetes mellitus (DM), cardiovascular disease, and </span>microvascular complications<span> inherent to DM, such as nephropathy, </span></span>neuropathy<span>, and retinopathy<span>. The fibrosis-4 (FIB-4) scoring system, a noninvasive tool, is useful for predicting the extent of liver fibrosis across diverse pathologies. This study aimed to assess the potential predictive role of FIB-4 scores in microvascular complications associated with diabetes.</span></span></span></p></div><div><h3>Patients and methods</h3><p><span><span><span>The medical records of patients with type 2 DM admitted to our </span>endocrinology clinic between February 2019 and December 2020 were retrospectively evaluated. Parameters including demographic attributes, fasting </span>blood glucose<span>, glycated hemoglobin, aspartate aminotransferase, </span></span>alanine aminotransferase, thrombocyte levels, and microvascular complications were recorded. The FIB-4 score was computed, and patients were categorized based on these scores (&lt;1.3 and ≥ 1.3).</p></div><div><h3>Results</h3><p><span><span>The analysis included 312 patients with a median age of 60 (50–68 years); 39.7 % were men. The median duration of diabetes was 10 years (5–20 years), and the median FIB-4 score was 0.93 (0.63–1.34). Neuropathy, nephropathy, and retinopathy were observed in 50.6 %, 31.4 %, and 34 % of the patients, respectively. Although the FIB-4 score did not differ significantly between patients with and without </span>neuropathy or retinopathy, patients with nephropathy exhibited higher FIB-4 scores. Notably, patients with FIB-4 scores ≥ 1.3 demonstrated a significantly higher prevalence of nephropathy. </span>Logistic regression analysis demonstrated that higher FIB-4 scores were significantly associated with an increased risk of nephropathy.</p></div><div><h3>Conclusion</h3><p>The FIB-4 score is a cost-effective and straightforward tool with potential applicability in predicting nephropathy in individuals with type 2 DM.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arab Journal of Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1687197924000388","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and study aims

Nonalcoholic fatty liver disease is the most prevalent chronic liver disease globally and is linked to augmented susceptibility to type 2 diabetes mellitus (DM), cardiovascular disease, and microvascular complications inherent to DM, such as nephropathy, neuropathy, and retinopathy. The fibrosis-4 (FIB-4) scoring system, a noninvasive tool, is useful for predicting the extent of liver fibrosis across diverse pathologies. This study aimed to assess the potential predictive role of FIB-4 scores in microvascular complications associated with diabetes.

Patients and methods

The medical records of patients with type 2 DM admitted to our endocrinology clinic between February 2019 and December 2020 were retrospectively evaluated. Parameters including demographic attributes, fasting blood glucose, glycated hemoglobin, aspartate aminotransferase, alanine aminotransferase, thrombocyte levels, and microvascular complications were recorded. The FIB-4 score was computed, and patients were categorized based on these scores (<1.3 and ≥ 1.3).

Results

The analysis included 312 patients with a median age of 60 (50–68 years); 39.7 % were men. The median duration of diabetes was 10 years (5–20 years), and the median FIB-4 score was 0.93 (0.63–1.34). Neuropathy, nephropathy, and retinopathy were observed in 50.6 %, 31.4 %, and 34 % of the patients, respectively. Although the FIB-4 score did not differ significantly between patients with and without neuropathy or retinopathy, patients with nephropathy exhibited higher FIB-4 scores. Notably, patients with FIB-4 scores ≥ 1.3 demonstrated a significantly higher prevalence of nephropathy. Logistic regression analysis demonstrated that higher FIB-4 scores were significantly associated with an increased risk of nephropathy.

Conclusion

The FIB-4 score is a cost-effective and straightforward tool with potential applicability in predicting nephropathy in individuals with type 2 DM.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
2 型糖尿病患者纤维化-4 评分与微血管并发症之间的关系。
背景和研究目的:非酒精性脂肪肝是全球发病率最高的慢性肝病,与2型糖尿病(DM)、心血管疾病和DM固有的微血管并发症(如肾病、神经病变和视网膜病变)的易感性增加有关。肝纤维化-4(FIB-4)评分系统是一种无创工具,可用于预测不同病理情况下的肝纤维化程度。本研究旨在评估 FIB-4 评分对糖尿病相关微血管并发症的潜在预测作用:回顾性评估了 2019 年 2 月至 2020 年 12 月期间内分泌科门诊收治的 2 型糖尿病患者的病历。记录的参数包括人口统计学属性、空腹血糖、糖化血红蛋白、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、血小板水平和微血管并发症。计算 FIB-4 评分,并根据这些评分对患者进行分类(结果:分析包括 312 名患者,中位年龄为 60 岁(50-68 岁);39.7% 为男性。糖尿病病程中位数为 10 年(5-20 年),FIB-4 评分中位数为 0.93(0.63-1.34)。分别有 50.6%、31.4% 和 34% 的患者出现神经病变、肾病变和视网膜病变。虽然 FIB-4 评分在有神经病变和视网膜病变的患者与无神经病变和视网膜病变的患者之间没有显著差异,但肾病患者的 FIB-4 评分较高。值得注意的是,FIB-4 评分≥ 1.3 的患者肾病患病率明显更高。逻辑回归分析表明,FIB-4评分越高,肾病风险越大:结论:FIB-4 评分是一种成本效益高且简单易行的工具,可用于预测 2 型糖尿病患者的肾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
期刊最新文献
"Mitigating tuberculosis reactivation risk in IBD patients on anti-TNF therapy". Epidemiological and anatomopathological profile of colorectal cancer in Northern Morocco between 2017 and 2019. Ginsenoside Rg3 enhances the anticancer effects of 5-fluorouracil in colorectal cancer and reduces drug resistance and the Hedgehog pathway activation. Effect of Lactobacillus acidophilus, Calcium, and Moringa oleifera leaves extract co-administration can prevent chemical-induced carcinogenesis. Current trends and research hotspots in the study of flavonoids for ulcerative colitis: A bibliometric study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1