Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis.

IF 8.1 1区 医学 Infectious Diseases of Poverty Pub Date : 2024-05-08 DOI:10.1186/s40249-024-01201-8
Pornphutthachat Sota, Morsid Andityas, Manas Kotepui, Banchob Sripa
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引用次数: 0

Abstract

Background: Opisthorchiasis and clonorchiasis, caused by Opisthorchis viverrini and Clonorchis sinensis, respectively, are significant yet neglected foodborne trematodiases in the Great Mekong Subregion (GMS). Despite the reporting of the prevalence of these human liver flukes in the region over the past decades, there has been a lack of a comprehensive and systematic consolidation of this data. Therefore, we aimed to conduct a thorough systematic review and meta-analysis to synthesize and analyze time-trend prevalence estimates of both O. viverrini and C. sinensis across the GMS for the past 30 years.

Methods: This study undertakes a systematic review using a comprehensive search for published articles in PubMed, EMBASE, Scopus, Cochrane and Thai Journal Online databases until early 2023. The pooled prevalence of O. viverrini and C. sinensis infection was analyzed through a random-effects meta-analysis, with meta-regression analysis used to quantify associations with study characteristics. Sub-group analysis was conducted, whenever comparison data were available, to assess the risk of O. viverrini and C. sinensis infection in each GMS country. Heterogeneity among studies was assessed using the Q statistic and quantified by using the I 2 Index.

Results: From a total of 2997 articles, 155 articles comprising 218 datasets and 751,108 participants were included for review. The GMS prevalence of O. viverrini was 21.11% [45,083/260,237; 95% confidence interval (CI): 17.74-24.47%]. Pooled prevalence estimates were highly observed in Laos (34.06%, 95% CI: 26.85-41.26%), followed by Thailand (18.19%, 95% CI: 13.86-22.51%), and Cambodia (10.48%, 95% CI: 5.52-15.45%). Myanmar and Vietnam had limited data sources for calculation. Clonorchis sinensis infection in GMS was 25.33% (95% CI: 18.32-32.34%), with Guangxi, China, exhibiting the highest prevalence rates at 26.89% (95% CI: 18.34-35.43%), while Vietnam had a prevalence rate of 20.30% (95% CI: 9.13-31.47%). O. viverrini prevalence decreased significantly over time, whereas C. sinensis infection appeared to be stable consistently over time in both China and Vietnam.

Conclusions: This comprehensive study, drawing from the largest datasets to date, offers an in-depth systematic prevalence review of human liver flukes in the Greater Mekong Subregion. It underscores the imperative for systematic surveillance, data collection, and the implementation of intervention and control measures for these infectious diseases of poverty.

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大湄公河次区域疟原虫(Opisthorchis viverrini)和中华疟原虫(Clonorchis sinensis)感染的流行率估计:系统回顾和荟萃分析。
背景:由Opisthorchis viverrini和Clonorchis sinensis分别引起的Opisthorchis病和Clonorchis病是大湄公河次区域(GMS)重要的食源性吸虫病,但却被忽视了。尽管在过去几十年中,该地区一直有关于这些人类肝吸虫流行情况的报道,但一直缺乏对这些数据进行全面系统的整合。因此,我们旨在进行一次全面的系统综述和荟萃分析,以综合分析过去30年里大湄公河次区域内O. viverrini和C. sinensis的时间趋势流行率估计值:本研究通过全面检索 PubMed、EMBASE、Scopus、Cochrane 和泰国期刊在线数据库中截至 2023 年初已发表的文章,进行了系统性回顾。通过随机效应荟萃分析法分析了O. viverrini和C. sinensis感染的总体流行率,并利用荟萃回归分析法量化了与研究特征的关联。只要有比较数据,就会进行分组分析,以评估每个大湄公河次区域国家的O. viverrini和C. sinensis感染风险。使用 Q 统计量评估研究之间的异质性,并使用 I 2 指数进行量化:结果:在总共 2997 篇文章中,有 155 篇文章、218 个数据集和 751 108 名参与者被纳入审查范围。O.viverrini的GMS流行率为21.11%[45,083/260,237;95%置信区间(CI):17.74-24.47%]。老挝的综合流行率估计值较高(34.06%,95% CI:26.85-41.26%),其次是泰国(18.19%,95% CI:13.86-22.51%)和柬埔寨(10.48%,95% CI:5.52-15.45%)。缅甸和越南的计算数据来源有限。大湄公河次区域的中华铃虫感染率为 25.33%(95% CI:18.32-32.34%),其中中国广西的感染率最高,为 26.89%(95% CI:18.34-35.43%),而越南的感染率为 20.30%(95% CI:9.13-31.47%)。随着时间的推移,O. viverrini 的感染率明显下降,而在中国和越南,C. sinensis 的感染率似乎一直保持稳定:这项综合研究利用了迄今为止最大的数据集,对大湄公河次区域人类肝吸虫的流行情况进行了深入系统的审查。它强调了对这些贫困传染病进行系统监测、数据收集以及实施干预和控制措施的必要性。
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来源期刊
Infectious Diseases of Poverty
Infectious Diseases of Poverty INFECTIOUS DISEASES-
自引率
1.20%
发文量
368
期刊介绍: Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.
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