Ventral Anterior Cingulate Atrophy as a Predisposing Factor for Transient Global Amnesia.

Dementia and neurocognitive disorders Pub Date : 2024-04-01 Epub Date: 2024-03-26 DOI:10.12779/dnd.2024.23.2.89

Jeewon Suh, Young Ho Park, Hang-Rai Kim, Jae-Won Jang, SangHak Yi, Min Ju Kang, Yun Jung Bae, Byung Se Choi, Jae Hyoung Kim, SangYun Kim

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Abstract

Background and purpose: This study aimed to evaluate the brain magnetic resonance imaging (MRI) of patients with acute transient global amnesia (TGA) using volumetric analysis to verify whether the brains of TGA patients have pre-existing structural abnormalities.

Methods: We evaluated the brain MRI data from 87 TGA patients and 20 age- and sex-matched control subjects. We included brain MRIs obtained from TGA patients within 72 hours of symptom onset to verify the pre-existence of structural change. For voxel-based morphometric analyses, statistical parametric mapping was employed to analyze the structural differences between patients with TGA and control subjects.

Results: TGA patients exhibited significant volume reductions in the bilateral ventral anterior cingulate cortices (corrected p<0.05).

Conclusions: TGA patients might have pre-existing structural changes in bilateral ventral anterior cingulate cortices prior to TGA attacks.

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腹侧前扣带回萎缩是短暂性全局失忆症的诱发因素。

背景和目的：本研究旨在利用容积分析评估急性短暂性全面遗忘（TGA）患者的脑部磁共振成像（MRI），以验证TGA患者的大脑是否预先存在结构异常：我们评估了 87 名 TGA 患者和 20 名年龄和性别匹配的对照组受试者的脑部 MRI 数据。我们纳入了TGA患者在症状出现72小时内获得的脑部核磁共振成像数据，以验证结构变化是否预先存在。在基于体素的形态计量分析中，我们采用了统计参数映射法来分析TGA患者与对照组之间的结构差异：结果：TGA 患者双侧腹侧前扣带回皮质的体积明显缩小（校正后的 p）：TGA患者在TGA发作前可能已经存在双侧腹侧前扣带回皮质的结构变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dementia and neurocognitive disorders

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