Adverse Food Reactions: Physiological and Ecological Perspectives.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2024-08-01 Epub Date: 2024-08-12 DOI:10.1146/annurev-nutr-061021-022909
Lisa L Korn, Vassily I Kutyavin, Nathaniel D Bachtel, Ruslan Medzhitov
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Abstract

While food is essential for survival, it can also cause a variety of harmful effects, ranging from intolerance to specific nutrients to celiac disease and food allergies. In addition to nutrients, foods contain myriads of substances that can have either beneficial or detrimental effects on the animals consuming them. Consequently, all animals evolved defense mechanisms that protect them from harmful food components. These "antitoxin" defenses have some parallels with antimicrobial defenses and operate at a cost to the animal's fitness. These costs outweigh benefits when defense responses are exaggerated or mistargeted, resulting in adverse reactions to foods. Additionally, pathological effects of foods can stem from insufficient defenses, due to unabated toxicity of harmful food components. We discuss the structure of antitoxin defenses and how their failures can lead to a variety of adverse food reactions.

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食物不良反应:生理学和生态学视角。
虽然食物是生存的必需品,但它也可能造成各种有害影响,从对特定营养素的不耐受到乳糜泻和食物过敏。除营养成分外,食物中还含有大量物质,这些物质对食用动物既可能产生有益影响,也可能产生有害影响。因此,所有动物都进化出了保护自己免受有害食物成分伤害的防御机制。这些 "抗毒素 "防御机制与抗微生物防御机制有一些相似之处,其运作需要动物付出一定的代价。当防御反应被夸大或目标错误,导致对食物产生不良反应时,这些代价就会得不偿失。此外,由于有害食物成分的毒性有增无减,防御能力不足也会导致食物产生病理效应。我们将讨论抗毒素防御系统的结构,以及它们的失效如何导致各种不良食物反应。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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