Interactions of Nutrition and Infection: The Role of Micronutrient Deficiencies in the Immune Response to Pathogens and Implications for Child Health.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2024-08-01 Epub Date: 2024-08-12 DOI:10.1146/annurev-nutr-062122-014910
Amanda C Palmer, Jacquelyn R Bedsaul-Fryer, Charles B Stephensen
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引用次数: 0

Abstract

Approximately five million children die each year from preventable causes, including respiratory infections, diarrhea, and malaria. Roughly half of those deaths are attributable to undernutrition, including micronutrient deficiencies (MNDs). The influence of infection on micronutrient status is well established: The inflammatory response to pathogens triggers anorexia, while pathogens and the immune response can both alter nutrient absorption and cause nutrient losses. We review the roles of vitamin A, vitamin D, iron, zinc, and selenium in the immune system, which act in the regulation of molecular- or cellular-level host defenses, directly affecting pathogens or protecting against oxidative stress or inflammation. We further summarize high-quality evidence regarding the synergistic or antagonistic interactions between MNDs, pathogens, and morbidity or mortality relevant to child health in low- and middle-income countries. We conclude with a discussion of gaps in the literature and future directions for multidisciplinary research on the interactions of MNDs, infection, and inflammation.

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营养与感染的相互作用:微量营养素缺乏在对病原体的免疫反应中的作用及其对儿童健康的影响》(The Role of Micronutrient Deficiency in the Immune Response to Pathogens and Implications for Child Health)。
每年约有 500 万儿童死于可预防的原因,包括呼吸道感染、腹泻和疟疾。其中大约一半的死亡原因是营养不良,包括微量营养素缺乏症(MNDs)。感染对微量营养素状况的影响已得到公认:对病原体的炎症反应会引发厌食症,而病原体和免疫反应都会改变营养吸收并造成营养流失。我们回顾了维生素 A、维生素 D、铁、锌和硒在免疫系统中的作用,它们在调节分子或细胞水平的宿主防御中发挥作用,直接影响病原体或防止氧化应激或炎症。我们进一步总结了与中低收入国家儿童健康相关的 MNDs、病原体、发病率或死亡率之间协同或拮抗相互作用的高质量证据。最后,我们讨论了文献中的不足之处,以及 MNDs、感染和炎症相互作用的多学科研究的未来方向。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
期刊最新文献
Adverse Food Reactions: Physiological and Ecological Perspectives. Does Maternal Diet Influence Future Infant Taste and Odor Preferences? A Critical Analysis. Helminth Infections and Diabetes: Mechanisms Accounting for Risk Amelioration. Interactions of Nutrition and Infection: The Role of Micronutrient Deficiencies in the Immune Response to Pathogens and Implications for Child Health. Energy Expenditure in Humans: Principles, Methods, and Changes Throughout the Life Course.
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