Yuxiuzi Xiao, Yuanzheng Hou, Jing Zeng, Yanping Gong, Lichao Ma
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引用次数: 0
Abstract
Objective: This study aimed to investigate the relationship between serum α-Klotho levels and insulin resistance (IR), a precursor to type 2 diabetes.
Methods: The study analyzed data from 4,758 adult participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. The relationship between α-Klotho concentration and IR was assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and odds ratios (OR) derived from logistic regression models.
Results: Results showed that every 1-ln increase in α-Klotho concentration raised the HOMA-IR value by 0.55 (95% confidence interval 0.35-0.74) and the odds of IR by 64% (odds ratio 1.64; 95% confidence interval 1.28-2.1). The odds of IR was 40% greater in highest tertile than in the lowest tertile.
Conclusion: The findings of this study underscore a significant correlation between increased serum α-Klotho levels and the prevalence of IR.
研究目的本研究旨在探讨血清α-Klotho水平与胰岛素抵抗（IR）（2型糖尿病的前兆）之间的关系：该研究分析了美国国家健康与营养调查（NHANES）中4758名成年参与者的数据，时间跨度为2007年至2016年。采用胰岛素抵抗稳态模型评估（HOMA-IR）和逻辑回归模型得出的几率（OR）评估了α-Klotho浓度与IR之间的关系：结果显示，α-Klotho浓度每增加1ln，HOMA-IR值就会增加0.55（95%置信区间为0.35-0.74），IR几率就会增加64%（几率比1.64；95%置信区间为1.28-2.1）。最高三分位数比最低三分位数发生 IR 的几率高 40%：本研究结果表明，血清α-Klotho水平升高与IR患病率之间存在显著相关性。
期刊介绍：
This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.
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