Prevalence of human herpesvirus in plasma and saliva of cirrhotic patients: A pilot study.

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Special Care in Dentistry Pub Date : 2024-05-10 DOI:10.1111/scd.13016

Gabriella Bueno Marinho, Juliana Bertoldi Franco, Jefferson R Tenório, Natália Silva Andrade, Rodrigo Melim Zerbinati, Janaína B Medina, Mário Pérez-Sayáns, Paulo Henrique Braz-Silva, Karem L Ortega

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Abstract

Aims: The objective of this study was to identify the presence of human herpesvirus (HHV) in the plasma and saliva of hepatic-cirrhosis patients and correlate it with clinical data and laboratory tests. This is a pilot, observational, and cross-sectional study.

Methods and results: Specimens of plasma and saliva from 72 cirrhotic individuals were analyzed by means of polymerase chain reaction. The patient population had a mean age of 54.84 years old (SD ± 10) and was 70% males (51/72). Approximately 47% (n = 34) of the patients had leukopenia and HHV was not identified in the plasma specimens. The main species of HHV identified in the saliva were HHV-7 (n = 42, 62%) and Epstein-Barr virus (EBV) (n = 30, 41%). Moreover, there was a significant decrease in the total number of leukocytes and lymphocytes in saliva containing EBV (P = .038 and P = .047, respectively).

Conclusion: The results show that the presence of EBV in the saliva of cirrhotic patients was correlated with their circulating immune status. It may be possible that the immune dysfunction displayed by the cirrhotic patients plays a role in the shedding of EBV into saliva.

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肝硬化患者血浆和唾液中人类疱疹病毒的流行情况：一项试点研究。

目的：本研究旨在确定肝硬化患者血浆和唾液中是否存在人类疱疹病毒（HHV），并将其与临床数据和实验室检测结果进行关联。这是一项试验性、观察性和横断面研究：通过聚合酶链反应分析了 72 名肝硬化患者的血浆和唾液标本。患者的平均年龄为 54.84 岁（SD ± 10），70% 为男性（51/72）。约 47% 的患者（n = 34）患有白细胞减少症，血浆标本中未发现 HHV。唾液中鉴定出的主要 HHV 类型为 HHV-7（42 人，62%）和 Epstein-Barr 病毒（EBV）（30 人，41%）。此外，含有 EBV 的唾液中白细胞和淋巴细胞总数明显减少（分别为 P = .038 和 P = .047）：结果表明，肝硬化患者唾液中 EBV 的存在与其循环免疫状态相关。结论：研究结果表明，肝硬化患者唾液中的 EBV 与他们的循环免疫状态相关，可能是肝硬化患者的免疫功能失调导致了 EBV 在唾液中的脱落。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Special Care in Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.40

自引率

14.30%

发文量

120

期刊介绍： Special Care in Dentistry is the official journal of the Special Care Dentistry Association, the American Association of Hospital Dentists, the Academy of Dentistry for Persons with Disabilities, and the American Society for Geriatric Dentistry. It is the only journal published in North America devoted to improving oral health in people with special needs.