Evaluating the Effect of Silver Diamine Fluoride, with or without Glutathione and Potassium Iodide, on Fluoride Release, Dentin Microhardness and Surface Properties of Dentin.

Abstract

This study aimed to evaluate the effect of silver diamine fluoride (SDF) in combination with or without glutathione (Glu) and potassium iodide (KI) on the fluoride release and the enhancement of dentin microhardness. In this et al study, 90 intact premolar teeth from human subjects were allocated into nine groups, each consisting of ten samples: A) control; B) SDF; C) SDF combined with 5% Glu; D) SDF combined with 10% Glu; E) SDF combined with 20% Glu; F) KI after SDF; G) 5% Glu after SDF; H) 10% Glu after SDF; and I) 20% Glu after SDF. Data were analyzed using SPSS version 22 software and ANOVA and post-hoc and repeated measure test (P value <0.05). Dentin microhardness exhibited variations across different treatments, with the highest value being observed in the SDF-5% Glu group and the lowest in the control group. However, there was a significant difference between the mean values of SDF-5% Glu group and the SDF group. Significant increases in microhardness were observed when comparing SDF-5% Glu to SDF+5% Glu and SDF-10% Glu to SDF+10% Glu in peer groups (P value <0.05). Over time, there was a significant increase in the amount of fluoride released as compared to the initial day. The utilization of SDF-5% Glu group exhibited the most favorable effect on improving dentin hardness. Additionally, utilizing Glu in concentrations of 5% and 10% after SDF application proved more effective in increasing dentin microhardness than combining it with SDF. Moreover, in all three fluoride measurement periods, adding 5% Glu to SDF and using 20% Glu following SDF administration led to a significant increase in fluoride release compared to the application of SDF alone.