Decreased Left Ventricular Mass is Associated with Sarcopenia and its Severity in Elderly Inpatients.

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Global Heart Pub Date : 2024-05-06 eCollection Date: 2024-01-01 DOI:10.5334/gh.1326

Yang Liu, Ling Li, Hui Gong, Xing Lyu, Lini Dong, Xiangyu Zhang

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Abstract

Objective: Skeletal muscle mass and cardiac structure change with age. It is unclear whether the loss of skeletal muscle mass (SMM) is accompanied by a decrease in heart mass loss. The aim of this study is to investigate the relationship of left ventricular mass (LVM) with sarcopenia and its severity in elderly inpatients.

Methods: Seventy-one sarcopenia subjects and 103 non-sarcopenia controls were enrolled in this study. Bioelectrical impedance analysis, handgrip strength, and 5-time chair stand test were used to evaluate SMM, muscle strength, and physical performance, respectively. Myocardial structure and function were assessed by echocardiography. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia criteria 2019.

Results: Sarcopenic patients had smaller left ventricular sizes and LVM than non-sarcopenic controls. Severe sarcopenic patients had smaller left ventricular sizes and LVM than non-severe sarcopenic patients. In univariate regression analysis, body mass index (BMI), cardiac size, and LVM were positively correlated with SMM or SMI. In multivariate regression analysis, BMI and LVM were independently correlated with SMM and SMI. The combined measurement of LVM and BMI predicts sarcopenia with 66.0% sensitivity and 88.7% specificity (AUC: 0.825; 95% CI: (0.761, 0.889); p < 0.001).

Conclusion: In hospitalized elderly patients, decreased left ventricular mass is associated with sarcopenia and its severity, and the combined measurement of LVM and BMI has a predictive value for sarcopenia.

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左心室质量下降与老年住院患者的 "肌少症 "及其严重程度有关

目的骨骼肌质量和心脏结构会随着年龄的增长而发生变化。目前尚不清楚骨骼肌质量（SMM）的减少是否伴随着心脏质量的减少。本研究旨在探讨老年住院患者左心室质量（LVM）与肌肉疏松症及其严重程度的关系：方法：本研究招募了 71 名肌肉疏松症受试者和 103 名非肌肉疏松症对照组受试者。生物电阻抗分析、手握力和 5 次椅子站立测试分别用于评估肌肉疏松症、肌肉力量和体能表现。心肌结构和功能通过超声心动图进行评估。根据2019年亚洲肌少症工作组标准诊断肌少症：与非肌少症对照组相比，肌少症患者的左心室尺寸和左心室容积较小。重度肌肉疏松患者的左心室尺寸和左心室容积均小于非重度肌肉疏松患者。在单变量回归分析中，体重指数（BMI）、心脏大小和 LVM 与 SMM 或 SMI 呈正相关。在多变量回归分析中，体重指数和左心室容积与 SMM 和 SMI 呈独立相关。结合测量 LVM 和 BMI 预测肌肉疏松症的灵敏度为 66.0%，特异度为 88.7%（AUC：结论：在住院老年患者中，左心室质量下降与肌肉疏松症及其严重程度相关，而左心室质量和体重指数的联合测量对肌肉疏松症具有预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.