Age-related changes in behavior profile in male offspring of rats treated with poly I:C-induced maternal immune activation in early gestation.

Q1 Health Professions Animal models and experimental medicine Pub Date : 2024-12-01 Epub Date: 2024-05-13 DOI:10.1002/ame2.12417

Tengfei Chen, Huadan Meng, Ni Fang, Peiling Shi, Mengxue Chen, Qing Liu, Luxian Lv, Wenqiang Li

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Abstract

Background: Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy. It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system.

Methods: Sprague-Dawley rats received a single caudal vein injection of 10 mg/kg polyinosinic:polycytidylic acid (poly I:C) on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood.

Results: Maternal serum levels of interleukin (IL)-6, IL-1β and tumor necrosis factor-α were elevated in poly I:C-treated dams. The offspring of maternal poly I:C-induced rats showed increased anxiety, impaired social approach, and progressive impaired cognitive and sensorimotor gating function.

Conclusion: Maternal immune activation led to developmental specificity behavioral impairment in offspring.

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妊娠早期母体免疫激活引起的多聚 I:C 大鼠雄性后代行为特征的年龄相关变化

背景：自闭症和精神分裂症是与怀孕期间产前病毒感染有关的环境风险因素。目前还不清楚母体免疫系统激活后，后代在不同发育阶段的行为表型是否会发生变化：方法：Sprague-Dawley大鼠在妊娠第9天接受一次尾静脉注射10毫克/千克多聚肌苷酸：多聚胞苷酸（poly I:C），对后代青春期和成年期的行为进行全面测试：结果：母体血清中白细胞介素（IL）-6、IL-1β和肿瘤坏死因子-α的水平在接受多聚 I:C 处理的母体中升高。母体多聚 I:C 诱导的大鼠的后代表现出焦虑增加、社会接近能力受损、认知和感觉运动门控功能逐渐受损：结论：母体免疫激活会导致后代发育特异性行为障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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