Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study.

IF 3 3区 心理学 Q2 CLINICAL NEUROLOGY Clinical Neuropsychologist Pub Date : 2024-05-13 DOI:10.1080/13854046.2024.2344869
Stefanos N Sampatakakis, Niki Mourtzi, Sokratis Charisis, Eirini Mamalaki, Eva Ntanasi, Alex Hatzimanolis, Alfredo Ramirez, Jean-Charles Lambert, Mary Yannakoulia, Mary H Kosmidis, Efthimios Dardiotis, Georgios Hadjigeorgiou, Maria Megalou, Paraskevi Sakka, Nikolaos Scarmeas
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Abstract

Objective: Our study aimed to explore whether physical condition might affect the association between genetic predisposition for Alzheimer's Disease (AD) and AD incidence. Methods: The sample of participants consisted of 561 community-dwelling adults over 64 years old, without baseline dementia (508 cognitively normal and 53 with mild cognitive impairment), deriving from the HELIAD, an ongoing longitudinal study with follow-up evaluations every 3 years. Physical condition was assessed at baseline through walking time (WT), while a Polygenic Risk Score for late onset AD (PRS-AD) was used to estimate genetic predisposition. The association between WT and PRS-AD with AD incidence was evaluated with Cox proportional hazard models adjusted for age, sex, education years, global cognition score and APOE ε-4 genotype. Then, the association between WT and AD incidence was investigated after stratifying participants by low and high PRS-AD. Finally, we examined the association between PRS-AD and AD incidence after stratifying participants by WT. Results: Both WT and PRS-AD were connected with increased AD incidence (p < 0.05), after adjustments. In stratified analyses, in the slow WT group participants with a greater genetic risk had a 2.5-fold higher risk of developing AD compared to participants with lower genetic risk (p = 0.047). No association was observed in the fast WT group or when participants were stratified based on PRS-AD. Conclusions: Genetic predisposition for AD is more closely related to AD incidence in the group of older adults with slow WT. Hence, physical condition might be a modifier in the relationship of genetic predisposition with AD incidence.

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步行时间与阿尔茨海默病的遗传倾向:HELIAD 研究的结果。
研究目的我们的研究旨在探讨身体状况是否会影响阿尔茨海默病(AD)遗传易感性与 AD 发病率之间的关联。研究方法参与者样本包括 561 名 64 岁以上、无痴呆症基线的社区成年人(508 人认知正常,53 人有轻度认知障碍),他们来自 HELIAD,这是一项正在进行的纵向研究,每 3 年进行一次随访评估。通过步行时间(WT)对基线身体状况进行评估,同时使用晚发性老年痴呆症多基因风险评分(PRS-AD)来估计遗传易感性。WT和PRS-AD与AD发病率之间的关系采用Cox比例危险模型进行评估,并对年龄、性别、受教育年限、总体认知评分和APOE ε-4基因型进行了调整。然后,根据低PRS-AD和高PRS-AD对参与者进行分层后,研究了WT与AD发病率之间的关系。最后,我们根据 WT 对参与者进行分层后,研究了 PRS-AD 与注意力缺失症发病率之间的关系。结果显示WT和PRS-AD都与AD发病率增加有关(P = 0.047)。在快速 WT 组或根据 PRS-AD 对参与者进行分层后,均未观察到两者之间的关联。结论注意力缺失症的遗传易感性与慢速 WT 组老年人的注意力缺失症发病率关系更为密切。因此,在遗传易感性与AD发病率的关系中,身体状况可能是一个调节因素。
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来源期刊
Clinical Neuropsychologist
Clinical Neuropsychologist 医学-临床神经学
CiteScore
8.40
自引率
12.80%
发文量
61
审稿时长
6-12 weeks
期刊介绍: The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.
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