Navigating neurological disorders: harnessing the power of natural compounds for innovative therapeutic breakthroughs.

IF 3.8 3区生物学 Q1 BIOLOGY EXCLI Journal Pub Date : 2024-04-23 eCollection Date: 2024-01-01 DOI:10.17179/excli2024-7051

Rapuru Rushendran, Rukaiah Fatma Begum, Ankul Singh S, Pavithra Lakshmi Narayanan, Chitra Vellapandian, Bhupendra G Prajapati, Pijush Kumar Paul

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Abstract

Novel treatments are needed as neurological issues become more frequent worldwide. According to the report, plants, oceans, microorganisms, and animals contain interesting drug discovery compounds. Alzheimer's, Parkinson's, and stroke reviews emphasize neurological disorders' complexity and natural substances' safety. Learn about marine-derived and herbal substances' neuroprotective characteristics and applications. Molecular pathways show these substances' neurological healing effects. This article discusses clinical usage of Bryostatin-1, Fucoidan, Icariin, Salvianolic acid, Curcumin, Resveratrol, etc. Their potential benefits for asthma and Alzheimer's disease are complex. Although limited, the study promotes rigorous scientific research and collaboration between traditional and alternative medical practitioners. Unexplored natural compounds, quality control, well-structured clinical trials, and interdisciplinary collaboration should guide future study. Developing and employing natural chemicals to treat neurological illnesses requires ethical sourcing, sustainability, and public awareness. This detailed analysis covers natural chemicals' current state, challenges, and opportunities in neurological disorder treatment. See also the graphical abstract(Fig. 1).

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导航神经系统疾病：利用天然化合物的力量实现创新治疗突破。

随着神经系统问题在全球范围内日益频繁，我们需要新的治疗方法。报告指出，植物、海洋、微生物和动物中都含有有趣的药物发现化合物。关于阿尔茨海默氏症、帕金森氏症和中风的综述强调了神经系统疾病的复杂性和天然物质的安全性。了解海洋和草本物质的神经保护特性和应用。分子途径显示了这些物质对神经系统的治疗作用。本文讨论了褐藻糖胶-1、褐藻糖胶、淫羊藿苷、丹酚酸、姜黄素、白藜芦醇等的临床应用。它们对哮喘和阿尔茨海默病的潜在益处十分复杂。尽管研究内容有限，但它促进了严谨的科学研究以及传统和替代医学从业者之间的合作。未开发的天然化合物、质量控制、结构合理的临床试验以及跨学科合作应成为未来研究的指导。开发和利用天然化学物质治疗神经系统疾病需要符合道德标准的来源、可持续性和公众意识。本报告详细分析了天然化学物质在治疗神经系统疾病方面的现状、挑战和机遇。另请参见图表摘要（图 1）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EXCLI Journal BIOLOGY-

CiteScore

8.00

自引率

2.20%

发文量

审稿时长

6-12 weeks

期刊介绍： EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences. The journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged (alphabetical order): aging research, behavioral sciences, biochemistry, cell biology, chemistry including analytical chemistry, clinical and preclinical studies, drug development, environmental health, ergonomics, forensic medicine, genetics, hepatology and gastroenterology, immunology, neurosciences, occupational medicine, oncology and cancer research, pharmacology, proteomics, psychiatric research, psychology, systems biology, toxicology