Topical Tretinoin in the Management of Thick-skinned Rhinoplasty Patients.

IF 0.9 Q3 SURGERY World Journal of Plastic Surgery Pub Date : 2024-01-01 DOI:10.61186/wjps.13.1.50
Hamidreza Rastiboroujeni, Mehdi Bakhshaee, Mohamad Reza Afzalzadeh, Yalda Nahidi
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Abstract

Background: Despite the increasing popularity of cosmetic surgeries, some patients still experience skin problems, particularly those with thick nasal skin. Isotretinoin is a commonly used drug for severe acne, and its effects on rhinoplasty aesthetic results have recently been studied. This placebo-controlled clinical trial aimed to investigate the effects of topical tretinoin gel on the cosmetic outcomes of rhinoplasty in patients with thick nasal skin.

Methods: Forty-nine individuals were randomly allocated to either the treatment group or the control group in Mashhad, Iran from 2019 to 2021. The treatment group received topical tretinoin gel (0.05%) beginning on the 31st postoperative day and continued for six months, while the control group received a usual dermatological recommendation as a placebo. Patients were assessed during the first, third, and sixth months after the intervention, and their cosmetic results were evaluated by an expert surgeon and dermatologist.

Results: There were no significant differences in baseline features between the two groups. The median score given by the surgeon was not significantly different between the groups. However, the median score given by the dermatologist was significantly higher in the treatment group during the first, third, and sixth months (P<0.001). Patient satisfaction scores were also significantly higher in the treatment group during the third and sixth months compared to the control group. (P=0.02 and 0.01, respectively).

Conclusion: Topical tretinoin gel could effectively reduce acne in patients with thick nasal skin after rhinoplasty and increase patient satisfaction in the early months following surgery. However, it did not significantly affect final cosmetic outcomes.

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外用曲安奈德治疗皮肤较厚的鼻整形术患者。
背景:尽管整容手术越来越受欢迎,但一些患者仍会遇到皮肤问题,尤其是鼻部皮肤较厚的患者。异维A酸是治疗严重痤疮的常用药物,最近有人研究了它对鼻整形美容效果的影响。这项安慰剂对照临床试验旨在研究局部使用曲安奈德凝胶对鼻部皮肤肥厚患者鼻整形手术美容效果的影响:方法:2019 年至 2021 年,在伊朗马什哈德,49 人被随机分配到治疗组或对照组。治疗组从术后第 31 天开始接受局部曲安奈德凝胶(0.05%)治疗,并持续 6 个月,而对照组则接受常规皮肤科建议作为安慰剂。在干预后的第一、第三和第六个月对患者进行评估,由外科医生和皮肤科专家对他们的美容效果进行评价:结果:两组患者的基线特征无明显差异。外科医生给出的中位数评分在两组之间没有明显差异。然而,治疗组在第一、第三和第六个月的皮肤科医生评分中位数明显更高(PP分别为0.02和0.01):外用曲安奈德凝胶可有效减少鼻整形术后鼻部皮肤肥厚患者的痤疮,并提高患者术后最初几个月的满意度。然而,它对最终的美容效果并无明显影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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