[Autoimmune Autonomic Ganglionopathy and Acute Autonomic Sensory Neuropathy].

Q3 Medicine Brain and Nerve Pub Date : 2024-05-01 DOI:10.11477/mf.1416202644
Shunya Nakane
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Abstract

Autoimmune autonomic ganglionopathy (AAG) and acute autonomic sensory neuropathy (AASN) are immune-mediated neuropathies that affect the autonomic and/or dorsal root ganglia. Autoantibodies against the nicotinic ganglionic acetylcholine receptor (gAChR) detected in the sera of patients with AAG play a key role in the pathogenesis of this condition. Notably, gAChR antibodies are not detected in the sera of patients with AASN. Currently, AAG and AASN are not considered to be on the same spectrum with regard to disease concept based on clinical symptoms and laboratory findings. However, extra-autonomic brain symptoms (including psychiatric symptoms and personality changes) and endocrine disorders occur in both diseases, which suggests shared pathophysiology between the two conditions.

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[自身免疫性自主神经节病和急性自主神经感觉神经病]。
自身免疫性自主神经节病(AAG)和急性自主神经感觉神经病(AASN)是由免疫介导的神经病,会影响自主神经和/或背根神经节。在 AAG 患者血清中检测到的烟碱性神经节乙酰胆碱受体(gAChR)自身抗体在这种疾病的发病机制中起着关键作用。值得注意的是,AASN 患者血清中未检测到 gAChR 抗体。目前,根据临床症状和实验室检查结果,AAG 和 AASN 在疾病概念上被认为不属于同一类型。然而,这两种疾病都会出现脑外自主神经症状(包括精神症状和人格改变)和内分泌紊乱,这表明这两种疾病具有共同的病理生理学特征。
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来源期刊
Brain and Nerve
Brain and Nerve Medicine-Neurology (clinical)
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