Design space identification of a coupled two-stage batch reactor system

Abstract

The design space (DS) is defined as the combination of materials and process conditions that guarantees the assurance of quality. This principle ensures that as long as a process operates within DS, it consistently produces a product that meets specifications. It was originally developed for a single unit system. Many industrial processes frequently involve multiple unit operations. Assessing the interaction of Critical Process Parameters (CPPs) with Critical Quality Attributes (CQAs) across stages enables informed decision-making and the capacity to balance different requirements. Analysis and visualization of the complex, multi-dimensional DS is a challenging task. This paper presents a framework for identification such DSs, considering both joint and decoupled strategies using a detailed analysis of a two-stage batch reactor case study. We assess and discuss the practicality and relevance of these methods.