Guanhong Bu, Emma Danelius, Lianne H.E. Wieske, Tamir Gonen
{"title":"Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED (Adv. Biology 5/2024)","authors":"Guanhong Bu, Emma Danelius, Lianne H.E. Wieske, Tamir Gonen","doi":"10.1002/adbi.202470051","DOIUrl":null,"url":null,"abstract":"<p><b>Macrocyclic Drug Structures by MicroED</b></p><p>Microcrystal electron diffraction (MicroED) is applied to capture two polymorphic structures of the elusive and flexible macrocyclic drug paritaprevir, which is used for treating chronic Hepatitis C virus (HCV) infection. Its potential interaction with the target HCV non-structural 3/4A serine protease is investigated by molecular docking. More details can be found in article number 2300570 by Tamir Gonen and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470051","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced biology","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adbi.202470051","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Macrocyclic Drug Structures by MicroED
Microcrystal electron diffraction (MicroED) is applied to capture two polymorphic structures of the elusive and flexible macrocyclic drug paritaprevir, which is used for treating chronic Hepatitis C virus (HCV) infection. Its potential interaction with the target HCV non-structural 3/4A serine protease is investigated by molecular docking. More details can be found in article number 2300570 by Tamir Gonen and co-workers.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
