Genetic protection against Alzheimer disease

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-05-14 DOI:10.1038/s41582-024-00968-6

Lisa Kiani

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预防阿尔茨海默病的基因保护

新的研究发现，认知健康的百岁老人因其有利的基因构成而免受阿尔茨海默病（AD）的侵害。对与阿兹海默症风险相关的86个单核苷酸多态性的分析表明，与阿兹海默症患者相比，认知健康的百岁老人中几乎所有增加风险的等位基因的频率都较低，而保护性等位基因的频率较高。差异最大的等位基因表明，内溶酶体和免疫系统途径是维持认知健康的关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.

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