A quantitative analysis of progressive fibrosing interstitial lung disease on computed tomography for the assessment of decreased vital capacity.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI:10.1177/02841851241246881

Yoshie Kunihiro, Tsuneo Matsumoto, Hideko Onoda, Tomoyuki Murakami, Masato Iduki, Yasushi Hirano, Katsuyoshi Ito

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Abstract

Background: The results of a quantitative analysis of computed tomography (CT) of interstitial lung disease (ILD) using a computer-aided detection (CAD) technique were correlated with the results of pulmonary function tests.

Purpose: To evaluate the correlation between a quantitative analysis of CT of progressive fibrosing interstitial lung disease (PF-ILD) including idiopathic pulmonary fibrosis (IPF) and non-IPF, which can manifest progressive pulmonary fibrosis and the vital capacity (VC), and to identify indicators for the assessment of a decreased VC.

Material and methods: A total of 73 patients (46 patients with IPF and 27 patients with non-IPF) were included in this study. Associations between the quantitative analysis of CT and the %VC using a CAD software program were investigated using Spearman's rank correlation and a logistic regression analysis. The appropriate cutoff vale for predicting a decreased VC was determined (%VC <80) and the area under the curve (AUC) was calculated.

Results: A multiple logistic regression analysis showed that the total extent of interstitial pneumonia on CT was a significant indicator of a decreased VC (P = 0.0001; odds ratio [OR]=1.15; 95% confidence interval [CI]=1.06-1.27 in IPF and P = 0.0025; OR=1.16; 95% CI=1.03-1.30 in non-IPF). The cutoff values of the total extent of interstitial pneumonia in IPF and non-IPF for predicting a decreased VC were determined to be 23.3% and 21.5%, and the AUCs were 0.83 and 0.91, respectively.

Conclusion: A quantitative analysis of CT of PF-ILD using a CAD software program could be useful for predicting a decreased VC.

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通过计算机断层扫描对进行性纤维化间质性肺病进行定量分析，以评估肺活量下降。

背景：目的：评估进行性纤维化间质性肺病（PF-ILD）（包括特发性肺纤维化（IPF）和非 IPF）CT 定量分析与肺活量（VC）之间的相关性，并确定肺活量下降的评估指标：本研究共纳入 73 名患者（46 名 IPF 患者和 27 名非 IPF 患者）。通过斯皮尔曼等级相关性和逻辑回归分析，研究了使用 CAD 软件程序进行的 CT 定量分析与 %VC 之间的关联。确定了预测 VC 下降的适当临界值（%VC 结果）：多重逻辑回归分析表明，CT 上间质性肺炎的总范围是 VC 下降的一个重要指标（IPF 患者的 P = 0.0001；几率比 [OR]= 1.15；95% 置信区间 [CI]= 1.06-1.27；非 IPF 患者的 P = 0.0025；OR=1.16；95% CI=1.03-1.30）。IPF和非IPF间质性肺炎总范围预测VC下降的临界值分别为23.3%和21.5%，AUC分别为0.83和0.91：结论：使用CAD软件程序对PF-ILD的CT进行定量分析有助于预测VC的下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta radiologica 医学-核医学

CiteScore

2.70

自引率

0.00%

发文量

170

审稿时长

3-8 weeks

期刊介绍： Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.