Changes in hearing function and intracochlear morphology after electrode array insertion in minipigs.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-01 Epub Date: 2024-05-14 DOI:10.1080/00016489.2024.2341122

Haiqiao Du, Jianan Li, Zhifeng Chen, Yun Gao, Xiao Yang, Shuolong Yuan, Qian Wang, Weiwei Guo, Wei Chen, Pu Dai, Shiming Yang

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Abstract

Background: In temporal bone specimens from long-term cochlear implant users, foreign body response within the cochlea has been demonstrated. However, how hearing changes after implantation and fibrosis progresses within the cochlea is unknown.

Objectives: To investigate the short-term dynamic changes in hearing and cochlear histopathology in minipigs after electrode array insertion.

Material and methods: Twelve minipigs were selected for electrode array insertion (EAI) and the Control. Hearing tests were performed preoperatively and on 0, 7, 14, and 28 day(s) postoperatively, and cochlear histopathology was performed after the hearing tests on 7, 14, and 28 days after surgery.

Results: Electrode array insertion had a significant effect for the frequency range tested (1 kHz-20kHz). Exudation was evident one week after electrode array insertion; at four weeks postoperatively, a fibrous sheath formed around the electrode. At each time point, the endolymphatic hydrops was found; no significant changes in the morphology and packing density of the spiral ganglion neurons were observed.

Conclusions and significance: The effect of electrode array insertion on hearing and intracochlear fibrosis was significant. The process of fibrosis and endolymphatic hydrops seemed to not correlate with the degree of hearing loss, nor did it affect spiral ganglion neuron integrity in the 4-week postoperative period.

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微型猪插入电极阵列后听觉功能和耳蜗内形态的变化

背景：在人工耳蜗长期使用者的颞骨标本中，耳蜗内的异物反应已被证实。然而，植入后听力如何变化以及耳蜗内纤维化如何发展尚不清楚：研究电极阵列植入后迷你猪听力和耳蜗组织病理学的短期动态变化：选取12只小猪作为电极阵列插入（EAI）和对照组。术前和术后0、7、14和28天进行听力测试，术后7、14和28天进行听力测试后进行耳蜗组织病理学检查：结果：电极阵列插入对测试频率范围（1 kHz-20 kHz）有显著影响。电极阵列插入一周后渗出明显；术后四周，电极周围形成纤维鞘。在每个时间点都发现了内淋巴水肿；螺旋神经节神经元的形态和堆积密度没有发生显著变化：电极阵列插入对听力和蜗内纤维化的影响显著。结论和意义：电极阵列插入对听力和耳蜗内纤维化的影响是显著的，纤维化过程和内淋巴水肿似乎与听力损失程度无关，也不影响术后 4 周螺旋神经节神经元的完整性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.