Antimicrobial and antibiofilm activities of Brazilian organic honey against oral microorganisms.

IF 2.1 4区生物学 Q3 MICROBIOLOGY Brazilian Journal of Microbiology Pub Date : 2024-09-01 Epub Date: 2024-05-15 DOI:10.1007/s42770-024-01343-9

Diego Romário-Silva, Marcelo Franchin, Severino Matias Alencar, Bruno Bueno-Silva, Janaína de Cássia Orlandi Sardi, Andréa Cristina Barbosa da Silva, Fabiane Cruz-Vieira, Priscila Vieira da Silva, Pedro Luiz Rosalen

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Abstract

Objective: To evaluate the antimicrobial activity of Brazilian honeys against oral microorganisms.

Design: Organic honeys (OH-1 to OH-8) were diluted (%-w/v) and sterilized by filtration. Antimicrobial activity was defined by determining MIC and CBM against oral Streptococcus. The component responsible for the antimicrobial action was defined by a catalase assay. Antibiofilm activity was evaluated against the monospecies biofilm of Streptococcus mutans (ATCC 700610).

Results: OHs showed antimicrobial activity principally OH-1, OH-2, OH-3, and OH-7 with MIC values ranging between 10 and 25%. The mechanism of action occurs mainly by hydrogen peroxide produced by honey enzymes. OH-1, OH-2, and OH-7 showed total biofilm destruction at low concentrations.

Conclusion: Brazilian honeys have promising antimicrobial and antibiofilm activity with the potential to control oral microbiota.

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巴西有机蜂蜜对口腔微生物的抗菌和抗生物膜活性。

目的：评估巴西蜂蜜对口腔微生物的抗菌活性：评估巴西蜂蜜对口腔微生物的抗菌活性：设计：将有机蜂蜜（OH-1 至 OH-8）稀释（%-w/v）并过滤灭菌。通过测定对口腔链球菌的 MIC 和 CBM 来确定抗菌活性。通过过氧化氢酶检测确定了抗菌作用的成分。针对变异链球菌（ATCC 700610）单菌种生物膜的抗生物膜活性进行了评估：结果：OHs 主要显示出 OH-1、OH-2、OH-3 和 OH-7 的抗菌活性，其 MIC 值介于 10% 和 25% 之间。其作用机制主要是蜂蜜酶产生的过氧化氢。OH-1、OH-2 和 OH-7 在低浓度下可完全破坏生物膜：巴西蜂蜜具有良好的抗菌和抗生物膜活性，具有控制口腔微生物群的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brazilian Journal of Microbiology 生物-微生物学

CiteScore

4.10

自引率

4.50%

发文量

216

审稿时长

1.0 months

期刊介绍： The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.