Correlation of Serum High-Sensitivity C-Reactive Protein, Homocysteine, and Macrophage Migration Inhibitory Factor Levels With Symptom Severity and Cognitive Function in Patients With Schizophrenia.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY Clinical Neuropharmacology Pub Date : 2024-05-01 DOI:10.1097/WNF.0000000000000594

Saizheng Weng, Rongyan Zheng, Ruiqian Lin

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Abstract

Objective: This trial analyzed high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), and macrophage migration inhibitory factor (MIF) level in serum and their correlation with symptom severity and cognitive function in patients with schizophrenia (SP).

Methods: Sixty-eight SP patients were enrolled in the SP group, and 68 healthy volunteers were in the control (CN) group. Serum hs-CRP, Hcy, and MIF were measured, and symptom severity was assessed with the Positive and Negative Symptom Scale (PANSS). Cognitive function was determined with the MATRICS Consensus Cognitive Battery (MCCB). The SP group was divided into high PANSS score (PANSS ≥70 points) and low PANSS score (PANSS <70 points), or the mild cognitive dysfunction group and severe cognitive dysfunction group according to the median MCCB score. The correlation between serum hs-CRP, Hcy, and MIF levels and PANSS and MCCB scores in SP patients was examined by Pearson correlation analysis.

Results: SP patients had higher serum hs-CRP, Hcy, and MIF levels and showed higher PANSS scores and lower MCCB total score. Serum hs-CRP, Hcy, and MIF levels in the high PANSS group were higher than those in the low PANSS group and in the severe cognitive dysfunction group than in the mild cognitive dysfunction group. Serum hs-CRP, Hcy, and MIF levels in SP patients were positively correlated with PANSS total score and negatively correlated with MCCB total score.

Conclusion: High serum hs-CRP, Hcy, and MIF levels in SP patients are correlated with symptom severity and cognitive dysfunction.

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精神分裂症患者血清高敏 C-反应蛋白、同型半胱氨酸和巨噬细胞迁移抑制因子水平与症状严重程度和认知功能的相关性。

试验目的该试验分析了精神分裂症（SP）患者血清中的高敏C反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）和巨噬细胞迁移抑制因子（MIF）水平及其与症状严重程度和认知功能的相关性：方法：68 名精神分裂症（SP）患者被纳入 SP 组，68 名健康志愿者被纳入对照（CN）组。测量血清 hs-CRP、Hcy 和 MIF，并用阳性和阴性症状量表（PANSS）评估症状严重程度。认知功能通过 MATRICS 共识认知测试（MCCB）进行测定。SP组分为PANSS高分（PANSS≥70分）和PANSS低分（PANSS结果≥70分）：SP患者的血清hs-CRP、Hcy和MIF水平较高，PANSS评分较高，MCCB总分较低。PANSS 高分组的血清 hs-CRP、Hcy 和 MIF 水平高于 PANSS 低分组，严重认知功能障碍组高于轻度认知功能障碍组。SP患者的血清hs-CRP、Hcy和MIF水平与PANSS总分呈正相关，与MCCB总分呈负相关：结论：SP 患者血清中的高 hs-CRP、Hcy 和 MIF 水平与症状严重程度和认知功能障碍相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.