The acute effect of exercise on the endothelial glycocalyx in healthy adults: A systematic review and meta-analysis

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL European Journal of Clinical Investigation Pub Date : 2024-05-15 DOI:10.1111/eci.14240

Alicia Saz-Lara, Iván Cavero-Redondo, Andrea del Saz-Lara, Eva Rodríguez-Gutiérrez, Bruno Bizzozero-Peroni, Carlos Pascual-Morena

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Abstract

Background

In recent years, it has been demonstrated that when the endothelial glycocalyx, composed of proteoglycans, glycosaminoglycans and glycoproteins, is altered or modified, this property is lost, playing a fundamental role in cardiovascular pathologies. Cardiovascular risk factors can destroy the endothelial glycocalyx layer. Exercise has a positive effect on cardiovascular risk factors, but little is known about its direct effect on the integrity of the endothelial layer.

Methods

The Cochrane Library, PubMed, Web of Science and Scopus databases were searched from their inception to June 30, 2022. The DerSimonian and Laird method was used to compute pooled effect size estimates and their respective 95% confidence intervals for the acute effect of exercise (within 24 h) on the endothelial glycocalyx and its components in healthy adults.

Results

Ten studies were included in the meta-analysis, with a total of 252 healthy subjects. The types of exercise included were resistance training, interval training, resistance training and maximal incremental exercise, with a duration range of 30–60 min. Glycocalyx assessment times included ranged from 0 to 90 min post-exercise. Our findings showed that endothelial glycocalyx increases after acute effect of exercise in healthy population (.56, 95% CI: .38, .74). The acute effect of exercise on endothelial glycocalyx components were .47 (95% CIs: .27, .67) for glycosaminoglycans, .67 (95% CIs: .08, 1.26) for proteoglycans and .61 (95% CIs: .35, .86) for glycoproteins.

Conclusions

In a healthy population, various types of exercise showed an acute improvement of the endothelial glycocalyx and its individual components.

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运动对健康成年人内皮糖萼的急性影响：系统回顾与荟萃分析。

背景：近年来的研究表明，当由蛋白聚糖、糖胺聚糖和糖蛋白组成的内皮糖萼层发生改变或修饰时，这种特性就会丧失，从而在心血管病变中扮演重要角色。心血管风险因素会破坏内皮糖萼层。运动对心血管风险因素有积极影响，但对运动对内皮层完整性的直接影响却知之甚少：方法：对 Cochrane 图书馆、PubMed、Web of Science 和 Scopus 数据库从开始到 2022 年 6 月 30 日进行了检索。采用 DerSimonian 和 Laird 方法计算运动（24 小时内）对健康成人内皮糖萼及其组成部分的急性影响的集合效应大小估计值及其各自的 95% 置信区间：荟萃分析共纳入了 10 项研究，涉及 252 名健康受试者。运动类型包括阻力训练、间歇训练、阻力训练和最大增量运动，持续时间范围为 30-60 分钟。糖萼评估时间从运动后 0 分钟到 90 分钟不等。我们的研究结果表明，在健康人群中，运动产生急性效应后内皮糖萼会增加（.56，95% CI：.38，.74）。运动对内皮糖萼成分的急性影响分别为：糖胺聚糖为.47（95% CIs：.27, .67），蛋白聚糖为.67（95% CIs：.08, 1.26），糖蛋白为.61（95% CIs：.35, .86）：结论：在健康人群中，各种类型的运动都能急性改善内皮糖萼及其各个组成部分。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.