Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary.

IF 3.7 3区生物学 Q1 DEVELOPMENTAL BIOLOGY Reproduction Pub Date : 2024-06-21 Print Date: 2024-08-01 DOI:10.1530/REP-23-0499

José V V Isola, Jessica D Hense, César A P Osório, Subhasri Biswas, José Alberola-Ila, Sarah R Ocañas, Augusto Schneider, Michael B Stout

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Abstract

In brief: Recent reports suggest a relationship between ovarian inflammation and functional declines, although it remains unresolved if ovarian inflammation is the cause or consequence of ovarian aging. In this review, we compile the available literature in this area and point to several current knowledge gaps that should be addressed through future studies.

Abstract: Ovarian aging results in reduced fertility, disrupted endocrine signaling, and an increased burden of chronic diseases. The factors contributing to the natural decline of ovarian follicles throughout reproductive life are not fully understood. Nevertheless, local inflammation may play an important role in driving ovarian aging. Inflammation progressively rises in aged ovaries during the reproductive window, potentially affecting fertility. In addition to inflammatory markers, recent studies show an accumulation of specific immune cell populations in aging ovaries, particularly lymphocytes. Other hallmarks of the aging ovary include the formation and accumulation of multinucleated giant cells, increased collagen deposition, and increased markers of cellular senescence. Collectively, these changes significantly impact the quantity and quality of ovarian follicles and oocytes. This review explores recent literature on the alterations associated with inflammation, fibrosis, cell senescence, and the accumulation of immune cells in the aging ovary.

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衰老卵巢中的炎症、免疫细胞和细胞衰老。

卵巢衰老会导致生育能力下降、内分泌信号紊乱以及慢性疾病负担加重。导致卵巢卵泡在整个生育期自然衰退的因素尚不完全清楚。然而，局部炎症可能在卵巢衰老中扮演着重要角色。在生殖窗口期，衰老卵巢中的炎症会逐渐升高，从而可能影响生育能力。除了炎症标志物外，最近的研究还显示衰老卵巢中特定免疫细胞群的积累，尤其是淋巴细胞。衰老卵巢的其他特征包括多核巨细胞的形成和积累、胶原蛋白沉积增加以及细胞衰老标志物增加。总之，这些变化对卵巢卵泡和卵母细胞的数量和质量产生了重大影响。本综述探讨了与衰老卵巢中炎症、纤维化、细胞衰老和免疫细胞堆积有关的最新文献。

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来源期刊

Reproduction 生物-发育生物学

CiteScore

7.40

自引率

2.60%

发文量

199

审稿时长

4-8 weeks

期刊介绍： Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.