Stage IV gastric adenocarcinoma with enteroblastic differentiation with 5-year relapse-free survival after D2 gastrectomy and chemotherapy: A case report.

IF 0.7 Q4 SURGERY Surgical Case Reports Pub Date : 2024-05-15 DOI:10.1186/s40792-024-01921-x

Hiroshi Nakayama, Tomonori Ida, Yui Hasegawa, Atsuhiko Sakamoto, Yoko Umezawa, Yuki Inaba, Hiroshi Nakada

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Abstract

Background: Gastric adenocarcinoma with enteroblastic differentiation (GACED), a rare subtype of gastric cancer, is associated with a more aggressive behavior than conventional gastric adenocarcinomas. We report a rare case of stage IV GACED treated with D2 gastrectomy and postoperative chemotherapy.

Case presentation: A 39-year-old woman with acute upper abdominal pain immediately underwent surgery for gastric perforation. Afterward she was diagnosed with adenocarcinoma of the pylorus. D2 gastrectomy was performed and the final pathological diagnosis was stage IV GACED with positive peritoneal cytology. Postoperative chemotherapy was initiated with S1 plus oxaliplatin for 1 year, which was ceased thereafter to enhance her quality of life. The patient survived more than 5 years without relapse after gastrectomy.

Conclusions: Stage IV GACED, determined by positive spalt-like transcription factor 4, can be successfully treated with surgery and chemotherapy.

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IV期胃腺癌伴肠细胞分化，D2胃切除术和化疗后5年无复发生存：病例报告。

背景：有肠细胞分化的胃腺癌（GACED）是一种罕见的胃癌亚型，与传统的胃腺癌相比更具侵袭性。我们报告了一例罕见的 IV 期 GACED 病例，患者接受了 D2 胃切除术和术后化疗：一名 39 岁女性因急性上腹部疼痛立即接受了胃穿孔手术。随后，她被诊断为幽门腺癌。她接受了 D2 胃切除术，最终病理诊断为 GACED IV 期，腹腔细胞学检查呈阳性。术后开始了为期一年的 S1 加奥沙利铂化疗，之后为提高生活质量停止了化疗。患者在胃切除术后存活了 5 年多，没有复发：通过spalt样转录因子4阳性确定的IV期GACED可以通过手术和化疗成功治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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