Enhanced adherence counselling outcomes among people living with HIV with virological failure: Single-centre experience in Pune, India.

IF 1.8 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES Chronic Illness Pub Date : 2024-09-01 Epub Date: 2024-05-15 DOI:10.1177/17423953241253869

Prajakta Kadale, Pallavi Shidhaye, Shraddha Gurav, Pournami Ap, Manisha Ghate

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Abstract

Objectives: World Health Organization has recommended enhanced adherence counselling (EAC) for people living with HIV (PLHIV) with virological failure. This study aimed to assess the outcomes of EAC and its associated factors among PLHIV with virological failure.

Methods: Data collected between March 2020 and February 2022 on viral load (VL) testing at antiretroviral therapy (ART) centre in Pune, India were reviewed. PLHIV with viral load ≥1000 copies/ml followed by three EAC sessions and a repeat viral load test were included. Multivariate logistic regression analysis was used to assess the factors associated with virological suppression (<1000 copies/ml).

Results: Of 170 PLHIV, 81 (47.6%) showed virological suppression. Being literate (p = 0.027), females (p = 0.021), on second-line ART regimen (p = 0.020), and with EAC initiation within a month (p = 0.016) were significantly associated with virological suppression. No association was found between reported barriers to treatment adherence and virological suppression.

Discussion: Early initiation of EAC is crucial for virological suppression among PLHIV with high viral load. It is important to highlight the significance of treatment adherence among individuals on first-line ART regimen. The use of effective visual tools during EAC sessions may help in achieving virological suppression among those with low literacy.

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提高病毒学检测失败的艾滋病病毒感染者的依从性咨询效果：印度浦那的单中心经验。

目标：世界卫生组织建议对病毒学检测失败的艾滋病病毒感染者（PLHIV）加强依从性咨询（EAC）。本研究旨在评估病毒学检测失败的艾滋病病毒感染者（PLHIV）的依从性咨询结果及其相关因素：研究回顾了 2020 年 3 月至 2022 年 2 月期间在印度浦那抗逆转录病毒疗法（ART）中心收集的病毒载量（VL）检测数据。其中包括病毒载量≥1000拷贝/毫升、接受过三次EAC治疗并重复进行病毒载量检测的PLHIV。采用多变量逻辑回归分析评估与病毒学抑制相关的因素（结果：在 170 名艾滋病毒感染者中，81 人（81%）接受了 EAC 治疗，其中有 1 人（81%）在 EAC 治疗后恢复了病毒学抑制：在 170 名艾滋病毒感染者中，有 81 人（47.6%）出现病毒抑制。识字（p = 0.027）、女性（p = 0.021）、接受二线抗逆转录病毒疗法（p = 0.020）以及在一个月内开始使用 EAC（p = 0.016）与病毒抑制显著相关。在报告的坚持治疗障碍与病毒学抑制之间未发现任何关联：讨论：对于病毒载量较高的艾滋病毒携带者而言，尽早开始 EAC 对病毒学抑制至关重要。强调一线抗逆转录病毒疗法患者坚持治疗的重要性非常重要。在EAC过程中使用有效的可视化工具可能有助于在文化水平较低的人群中实现病毒抑制。

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来源期刊

Chronic Illness Multiple-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： Chronic illnesses are prolonged, do not resolve spontaneously, and are rarely completely cured. The most common are cardiovascular diseases (hypertension, coronary artery disease, stroke and heart failure), the arthritides, asthma and chronic obstructive pulmonary disease, diabetes and epilepsy. There is increasing evidence that mental illnesses such as depression are best understood as chronic health problems. HIV/AIDS has become a chronic condition in those countries where effective medication is available.