Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles-Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg Gevers, Benedetta Terziroli Beretta-Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group
{"title":"Elevated polyreactive immunoglobulin G in immune mediated liver injuries with the need for immunosuppressive therapy","authors":"Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles-Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg Gevers, Benedetta Terziroli Beretta-Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group","doi":"10.1101/2024.05.04.24306873","DOIUrl":null,"url":null,"abstract":"<strong>Background and aim</strong> The distinction of drug-induced liver injury (DILI), drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker with a higher accuracy for the diagnose of AIH than conventional autoantibodies. This retrospective multicenter study aimed to evaluate the diagnostic accuracy of pIgG to distinguish between AIH, DI-ALH and DILI and thus identify patients in need of immunosuppression.","PeriodicalId":501258,"journal":{"name":"medRxiv - Gastroenterology","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.04.24306873","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background and aim The distinction of drug-induced liver injury (DILI), drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker with a higher accuracy for the diagnose of AIH than conventional autoantibodies. This retrospective multicenter study aimed to evaluate the diagnostic accuracy of pIgG to distinguish between AIH, DI-ALH and DILI and thus identify patients in need of immunosuppression.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
