A facile halogen assisted intramolecular cyclization of (E)-3-(substituted benzylidene)-1-(substituted phenyl)pyrrolidine-2,5-dione

Abstract

A straightforward method for producing pyrrolo-chromenes involved the utilization of a Wittig reaction, where maleimides reacted with ortho-hydroxy benzaldehyde. This reaction yields ortho-hydroxy benzylidine succinimides, which subsequently undergo molecular bromine-induced intramolecular cyclization, resulting in (E)-3-(substituted benzylidine)-1-(substituted phenyl) pyrrolidine-2,5-dione derivatives (6g-n). The traditional reaction methods demonstrates efficient performance when carried out in a DMF solvent. This approach proves to be user-friendly and provides numerous benefits, including reduced reaction duration, increased product yields, and milder operating conditions. The compounds synthesized in this study will be integrated into our biological screening program and any discoveries pertaining to their biological properties will be further investigated and subsequently documented.