A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography

IF 0.8 4区 化学 Q4 SPECTROSCOPY Journal of Applied Spectroscopy Pub Date : 2024-05-10 DOI:10.1007/s10812-024-01725-9
R. R. Davletshin, R. R. Galeev, I. R. Aryslanov, E. V. Galeeva, A. N. Sedov
{"title":"A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography","authors":"R. R. Davletshin,&nbsp;R. R. Galeev,&nbsp;I. R. Aryslanov,&nbsp;E. V. Galeeva,&nbsp;A. N. Sedov","doi":"10.1007/s10812-024-01725-9","DOIUrl":null,"url":null,"abstract":"<p>High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluate the quality of an amoxicillin sample obtained after thermal degradation at 80°C.</p>","PeriodicalId":609,"journal":{"name":"Journal of Applied Spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Spectroscopy","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10812-024-01725-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
引用次数: 0

Abstract

High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluate the quality of an amoxicillin sample obtained after thermal degradation at 80°C.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
利用拉曼光谱和高效液相色谱法对三水阿莫西林热降解的研究
高效液相色谱法(HPLC)和拉曼光谱被用来研究三水阿莫西林的热降解。将这种化合物在 60°C 下加热 6 小时会导致杂质含量增加,但每个杂质含量都不超过 1%。高效液相色谱法和拉曼光谱可用于评估在 80°C 热降解后获得的阿莫西林样品的质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
1.30
自引率
14.30%
发文量
145
审稿时长
2.5 months
期刊介绍: Journal of Applied Spectroscopy reports on many key applications of spectroscopy in chemistry, physics, metallurgy, and biology. An increasing number of papers focus on the theory of lasers, as well as the tremendous potential for the practical applications of lasers in numerous fields and industries.
期刊最新文献
Analysis of Spatial Distributions of the Number of Photon Counts in Fluorescence Fluctuation Spectroscopy Identification and Detection of Adulterated Butter by Colorimetry and Near-IR-Spectroscopy Quantitative Spectrophotometric Determination of Cerium Dioxide Nanoparticles in Oxidized Bacterial Cellulose The Anomalous Skin Effect in Metallic Films Spectroscopic and Thermal Study of the Cyanide-Bridged Heteronuclear Compounds [Cd(NH3)(μ-3-Aminomethylpyridine)M(μ-CN)4]N [M: Pd(II) or Pt(II)]
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1